The University of Texas System

Jun Yang

Mien-Chie Hung

Dihua Yu

Xiaoyan Zhou

Ping Li

Wentao Yang

Jun Yao

Christopher L Neal

Raphael E Pollock

Nina T Nguyen

Frederick F Becker

Xiao-Bo Wang

Ying Chi Huang

Peter R C Gascoyne

Methods of determining prognosis in a subject with a hyperproliferative disease, including determining expression and/or function of 14-3-3 zeta in the subject, are disclosed. Also disclosed are methods of making a pharmaceutical agent that modulates apoptosis, including the steps of obtaining one or more candidate, testing the one or more candidate substances to determine their ability to modulate the expression and/or function of 14-3-3 zeta, selecting a candidate substance determined to modulate the expression and/or function of 14-3-3 zeta, and making a pharmaceutical composition that includes the selected candidate substance. In addition, methods of treating a subject with a hyperproliferative disease, including making a pharmaceutical agent by the methods set forth herein, and administering the pharmaceutical agent to a subject, are disclosed. The hyperproliferative disease can be cancer, such as breast cancer.

14-3-3 Zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer type

14-3-3 zeta over-expression as a poor prognosis factor, and a therapeutic target in multiple cancer types

Methods and apparatus for discriminating matter in a chamber having an inlet port and an outlet port utilizing dielectrophoresis and field flow fractionation. A carrier medium is introduced into the inlet port and is directed from the inlet port to the outlet port according to a velocity profile. A programmed voltage signal is applied to an electrode element coupled to the chamber to form a dielectrophoretic force on the matter. The dielectrophoretic force is balanced with a gravitational force to displace the matter to positions within said velocity profile in the carrier medium to discriminate the matter. A chamber having a top and bottom outlet port may be utilized to withdraw a first portion of a carrier medium from the top outlet port at a first, controllable fluid flow rate and to withdraw a second portion of the carrier medium from the bottom outlet port at a second, controllable fluid flow rate.

Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation

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Houston, TX, United States of America

Jun Yang