Huawei Technologies Co., Limited

Hangzhou Yixiang Technology Research and Development Co., Ltd.

Nanjing Topto Materials Co., Ltd.

Banma Zhixing Network (Hongkong) Co., Limited

Hangzhou Normal University

Other

Microstrategy, Inc.

Ribon Therapeutics, Inc.

Zhejiang Benli Technology Co., Ltd.

Jun Xu

Yuangang Wang

Qun Yu

Guanyu Zhu

Yulin Ye

Jianing Zhu

Baichen Dong

Xuejin Yang

Junfeng Zhao

Chao Qian

Jin Woo Kim

Linlin Wang

Dening Wang

Pengfei Zhang

Licheng Chen

Chao Shen

Yunfeng Shao

Wenlong Huang

Kevin Wayne Kuntz

Masood Mortazavi

Xing Hu

Xiao Yang

Huan Yun Zhang

Laurie B Schenkel

Liang Shi

Kerren Kalai Swinger

Melissa Marie Vasbinder

Yongbing Huang

Weiming Xu

Xiaoling Li

Haiyan Liu

Qiao Li

Fen Dai

Hao Xiao

Changliang Xue

Zheng Yan

Yingdong Zhang

Chun Xue

Dongfang Shan

Ruidan Zhu

Xin He

Jiabin Shen

Meng Jiang

Donghui Zhuo

Haijun Shan

Tianxiang Li

Ying Huang

Huaqing Wang

Yin Hong

Yinwei Zhu

Jianqun Shi

Xinxin Chen

Shuli Zhao

Caizhu Luo

Haining Gu

The present invention relates to solid forms of the poly(ADP-ribose) polymerase 7 (PARP7) inhibitor 5-[[(2S)-1-(3-oxo-3-[4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl]propoxy)propan-2-yl]amino]-4-(trifluoromethyl)-2,3-dihydropyridazin-3-one, and salts thereof, including methods of preparation thereof, where the inhibitor is useful in the treatment of cancer.

Solid forms of a PARP7 inhibitor

Deck box

Heater

A storage system includes a management node and a plurality of storage nodes forming a redundant array of independent disks (RAID). When the management node determines that not all data in an entire stripe is updated based on a received write request, the management node sends an update data chunk obtained from to-be-written data to a corresponding storage node. The storage node does not directly update, based on the received update data chunk, a data block stored in a storage device of the storage node, but store the update data chunk into a non-volatile memories (NVM) cache of the storage node and send the update data chunk to another storage node for backup. According to the data updating method, write amplification problems caused in a stripe update process can be reduced, thereby improving update performance of the storage system.

Data updating technology

A file management method, a distributed storage system, and a management node are disclosed. In the distributed storage system, after receiving a file creation request sent by a host for requesting to create a file in a distributed storage system, a management node allocates, to the file, first virtual space from global virtual address space of the distributed storage system, where local virtual address space of each storage node in the distributed storage system is corresponding to a part of the global virtual address space. Then, the management node records metadata of the file, where the metadata of the file includes information about the first virtual space, and the information about the first virtual space is used to point to local virtual address space of a storage node that is used to store the file. Further, the management node sends, the information about the first virtual space to the host.

File management method, distributed storage system, and management node

Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for high-throughput parallel data transmission. In some implementations, a data connector module is configured to provide an application server with access to a data set of unstructured data. One or more computers receive a first request associated with a first application or service, and data identifying a second application or service different from the first application or service. A plurality of second requests are generated and distributed to processing nodes to generate results for the second requests. Result data derived from the results for the second requests to the second application or service.

High-throughput parallel data transmission

A storage system includes a management node and a plurality of storage nodes forming a redundant array of independent disks (RAID). When the management node determines that not all data in an entire stripe is updated based on a received write request, the management node sends update data chunk obtained from to-be-written data to corresponding storage node. The storage node do not directly update, based on the received update data chunks, data block stored in storage device of the storage node, but store the update data chunk into non-volatile memories (NVM) cache of the storage node and send the update data chunk to another storage node to backup. According to the data updating method, write amplification problems caused in a stripe update process can be reduced, thereby improving update performance of the storage system.

The present invention relates to the technical field of chemical synthesis of pharmaceutical chemicals, and provides a 6H-imidazo[4,5,1-ij]quinolone, a synthesis method and use thereof. 6H-imidazo[4,5,1-ij]quinolone derivatives provided by the present invention are a novel group of active quinolone derivatives, which have tumor cell inhibition activity and exhibit ICvalues equivalent to anti-lung cancer drug osimertinib; these quinolone derivatives have a broad application prospect in the preparation of antitumor drugs. The 6H-imidazo[4,5,1-ij]quinolone provided by the present invention is of high research and application value and has potential application prospects in fields of pharmaceutical chemicals, materials, dyes, etc. The present invention uses thioquinolinamide as a raw material to synthesize 6H-imidazo[4,5,1-ij]quinolones, featuring simple operation, excellent selectivity, high yield, mild reaction conditions, and easy product separation.

6H-imidazo[4,5,1-ij]quinolone, synthesis method and use thereof

The method and apparatus that are applied to a machine learning system which includes at least one parameter collection group and at least one parameter delivery group. Each parameter collection group is corresponding to at least one parameter delivery group. The method includes: when any parameter collection group meets an intra-group combination condition, combining model parameters of M nodes in the parameter collection group to obtain a first model parameter of the parameter collection group, where a smallest quantity s of combination nodes in the parameter collection group&#x2264;M&#x2264;a total quantity of nodes included in the parameter collection group; and sending the first model parameter of the parameter collection group to N nodes in a parameter delivery group corresponding to the parameter collection group, where 1&#x2264;N&#x2264;a total quantity of nodes included in the parameter delivery group corresponding to the parameter collection group.

Model parameter combination method and apparatus

Embodiments of the present invention provide a model parameter fusion method and apparatus, which relate to the field of machine learning and intend to reduce a data transmission amount and implement dynamical adjustment of computing resources during model parameter fusion. The method includes: dividing, by an inode, a model parameter of the inode into N blocks, where the inode is any node of N nodes that participate in a fusion, and 1&#x2264;i&#x2264;N&#x2264;M; receiving, by the inode, imodel parameter blocks respectively sent by other nodes of the N nodes than the inode; fusing, by the inode, an imodel parameter block of the inode and the imodel parameter blocks respectively sent by the other nodes, so as to obtain the igeneral model parameter block; and distributing, by the inode, the igeneral model parameter block to the other nodes of the N nodes.

Model parameter fusion method and apparatus

An access request processing method is performed by a computer device that includes a processor, a dynamic random-access memory (DRAM), and a non-volatile memory (NVM). When receiving a write request, the processor may identify an object cache page according to the write request. The processor obtains the to-be-written data from a buffer according to a buffer pointer in the write request, the to-be-written data including a new data chunk to be written into the object cache page. The processor then inserts a new data node into a log chain of the object cache page, where the NVM stores data representing the log chain of the object cache page. The new data node includes information regarding the new data chunk of the object cache page. The computer device provided in this application can reduce system overheads while protecting data consistency.

Access request processing method and apparatus, and computer device

A file page table management method. The file page table management method is applied to a storage system in which a file system is created in a memory. According to the file page table management method, a mapping manner of a file page table can be dynamically adjusted based on an access type of an access request for accessing the memory, thereby improving memory access efficiency and saving memory space.

File page table management technology

A capacity expansion method includes obtaining a measured workload of a service of an application, obtaining an application model of the application, and obtaining a measured workload of each upper-level service of the service; determining a predicted workload of the service based on the measured workload of the service, determining the measured workload of each upper-level service of the first service, and determining a first workload ratio corresponding to a first calling relationship; and determining a predicted workload of each lower-level service based on the predicted workload of the service and determining a second workload ratio corresponding to a second calling relationship.

Capacity expansion method and apparatus

Growing community of inventors

Hangzhou, China

Jun Xu