The Procter Gamble Company

General Electric Company

Precisionbiotics Group Limited

Alimentary Health Limited

Jun Xu

Robert Lloyd Binder

Robert Scott Youngquist

Charles Winston Saunders

Jeffrey John Scheibel

Timothy James Held

Phillip Richard Green

Kenneth Nathan Price

David Johnathan Kitko

Stephanie Ann Urbin

Mark Anthony Mueller

Wenzhu Zhao

Tomohiro Hakozaki

Charles Carson Bascom

Liam Diarmuid O'Mahony

Howard David Hutton, Iii

Rosemarie Osborne

John David Carter

Duane Larry Charbonneau

Douwe Van Sinderen

Kevin John Mills

Ping Hu

Raymond Alan Grant

Faiz Feisal Sherman

Phillip Kyle Vinson

Zaiyou Liu

James Robert Schwartz

Jorge Max Sunkel

Michael Louis Vermeersch

Casey Patrick Kelly

Scott Michael Hartman

Kenton Duane Juhlin

Keith Robert McManus

Deborah Ruth Finlay

Toshiyuki Iwata

Elaine Marie Burt

Makio Tamura

Teresa DiColandrea

Brian Wilson Howard

Thomas Larry Dawson

David Blair Cody

Thomas Walter Federle

Shannon Christine Weitz

Venkatraman Ananthakrishnanlyer

Zhongtao Dai

Song Yuli

Wenzhu (Steven) Zhao

Yuli Song

Liam O'mahony

Zubin Sarosh Khambatta

Leo Timothy Ii Laughlin

Jeffrey Kenneth Domsic

Robie Lynn Lucas

Wenzhu Steven Zhao

Raymond A Grant

Systems and methods for providing customized skin care product recommendations. The system utilizes an image capture device and a computing device coupled to the image capture device. The computing device causes the system to analyze a captured image of a user via the by processing the image through a convolutional neural network to determine a skin age of the user. Determining the skin age may include identifying at least one pixel that is indicative of the skin age and utilizing the at least one pixel to create a heat map that identifies a region of the image that contributes to the skin age. The system may be used to determine a target skin age of the user, determine a skin care product for achieving the target skin age, and provide an option for the user to purchase the product.

Systems and methods for providing customized product recommendations

The multiple embodiments described herein comprise the genome of a probioticbifidobacteria strain and genes encoded by the genome. Various novelare described.

A method for making a skin care composition by identifying connections between cosmetic agents and genes associated with one or more skin aging conditions. The method includes accessing a plurality of instances and at least one skin aging gene expression signature, comparing the at least one skin aging gene expression signature to the plurality of the instances, assigning a connectivity score to each instance based on the comparison and incorporating the cosmetic agent into a skin care composition when the connectivity score of the instance associated with the cosmetic agent has a negative correlation.

Method of making skin care compositions

A method of generating a hyperpigmentation condition gene expression signature for use in identifying connections between perturbagens and genes associated with a skin pigmentation condition. The method includes providing a gene expression profile for a reference sample of human skin cells not affected with a pigmentation condition; generating a gene expression profile for a sample of human skin cells from a subject exhibiting the hyperpigmentation condition; comparing the expression profiles to determine a gene expression signature that includes a set of differentially expressed genes; assigning an identifier to each gene constituting the gene expression signature and ordering the identifiers according to the direction of differential expression to create one or more gene expression signature lists; and storing the one or more gene expression signature lists on at least one computer readable medium.

Method of generating a hyperpigmentation condition gene expression signature

A method of formulating a skin-lightening composition by identifying actives with a data architecture and incorporating the actives into a skin care composition. The data architecture can be used to identify connections between perturbagens and genes associated with skin tone. A gene expression profile for a control human cell is compared to the gene expression profile a cell exposed to perturbagen to identify the genes which are differentially expressed. The differentially expressed genes are analyzed and arranged into an ordered list of identifiers, which along with other instances create a data architecture.

Method of formulating a skin-lightening composition

A method of constructing a data architecture for use in identifying connections between perturbagens and genes associated with skin tone. The method includes providing a gene expression profile for a control cell, generating a gene expression profile for a cell exposed to a perturbagen, identifying genes differentially expressed in response to the perturbagen, creating an ordered list of identifiers, storing the ordered list as an instance on a computer readable medium, and constructing a data architecture of stored instances.

Method of constructing a data architecture

Methods and systems for determining functional relationships between a skin-active agent and a skin condition of interest, and methods and systems for identifying cosmetic agents effective for treatment of dandruff, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both are provided. Methods for developing in vitro models of skin disease and models for specific skin diseases are also provided.

Systems, models and methods for identifying and evaluating skin-active agents effective for treating dandruff/seborrheic dermatitis

Methods and systems for constructing a gene expression signature representative of a number of biological conditions, systems and methods for determining functional relationships between a skin-active agent and skin conditions of interest, and methods and systems for identifying skin-active agents with broad spectrum activity are provided.

Systems, models and methods for identifying and evaluating skin-active agents effective for treating an array of skin disorders

Provided are methods and systems for determining functional relationships between a cosmetic agent and a hair biology condition of interest. Also provided are methods and systems for identifying cosmetic agents that affect a hair biology condition, as well as the use of agents identified by such methods and systems for the preparation of cosmetic compositions, personal care products, or both.

Systems and methods for identifying cosmetic agents for hair/scalp care compositions

Bifidobacterium longum

A system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition. The system includes a computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature. Each instance comprises an ordered list of identifiers representing a plurality of differentially expressed genes generated as a result of contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The computing device includes computer-readable instructions for accessing the plurality of instances and the skin aging gene expression signature stored on the computer readable medium, comparing each of the instances to the skin aging gene expression signature, and assigning a connectivity score to each of the instances based on the comparison.

Systems for identifying cosmetic agents for skin care compositions

The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.

Inhibition of microbial growth by aconitase inhibition

Disclosed herein are novel mixtures of scattered-branched chain fatty acids and derivatives of scattered-branched chain fatty acids. Further disclosed are uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).

Intermediates and surfactants useful in household cleaning and personal care compositions, and methods of making the same

Disclosed herein are novel mixtures of near terminal-branched compounds and derivatives thereof. Further disclosed are methods of making these mixtures, and uses of these mixtures in cleaning compositions (e.g., dishcare, laundry, hard surface cleaners,) and/or personal care compositions (e.g., skin cleansers, shampoo, hair conditioners).

Compositions comprising a near terminal-branched compound and methods of making the same

Method of cleansing hair comprising: (a) applying a composition to the hair; (b) dissolving and lathering the composition using a water-based solvent; (c) rinsing the hair with a water-based solvent; wherein during the rinsing a total of about 100 gram to about 300 gram of water-based solvent per gram of hair (dry weight) is employed; wherein the composition comprises from about 3 wt % to about 35 wt % of a mixture of at least two compounds of Formula I.

Method of cleansing hair

Growing community of inventors

Mason, OH, United States of America

Jun Xu