South China University of Technology

Sun Yat-sen University Cancer Center

Guangzhou Hkhpah Commodity Co., Ltd.

Guangzhou Riton Biomaterial Co., Ltd

Jun Wang

Zhiyong Wang

Qian Zhong

Qianni Ye

Xiaojiao Du

Song Shen

Mengqing Zhang

Youyong Yuan

Guokai Feng

Xing Zhang

Xianzhu Yang

Musheng Zeng

Zhiting Cao

Weihong Huang

Zu'an Li

Tingjin Zhong

Shanmin Fu

Hongwei Wang

The disclosure relates to a protein-type nanoparticle for multi-specific antibody delivery, a preparation method, and its application. The protein-type nanoparticle includes a polyester and a protein with a hydrophobic domain, and the hydrophobic domain of the protein is bound with the polyester through hydrophobic interactions. The protein is at least one of albumin, globulin and cell wall protein. The protein-type nanoparticle of the present disclosure has excellent stability and biocompatibility. The protein-type nanoparticle is used to prepare a multi-specific antibody delivery platform (αFc-NP) by binding anti-IgG-Fc antibody or anti-IgG-Fc antibody fragment, which can stably, quickly and easily bind to multiple specific antibodies through antigen-antibody interaction and enhance the therapeutic effect of specific antibodies.

Protein-type nanoparticles, preparation methods, and application thereof

A tumor-targeting peptide is disclosed. This tumor-targeting peptide comprises a typical motif with the general formula of: XX(Y/F) (D/E) (D/E) XX. The motif is selectively connected with 1-3 amino acids at the C-terminal and/or N-erminal. X represents any one of the twenty natural amino acids or the D type amino acids. The present invention also discloses that the peptide can not only target tumor vessels and tumor cells but also penetrate them and thus can be applied in tumor diagnosis and therapy.

Tumor-targeting polypeptide and application thereof

Multi-function trolley case with retractable table and chair

Growing community of inventors

Guangzhou, China

Jun Wang