Dsm IP Assets B.v.

Jun Wang

Ross E Zirkle

James Casey Lippmeier

Kirk Emil Apt

David John Simpson

James P Wynn

James George Metz

Bastien Chevreux

Anne-Cecile V Bayne

The present invention relates to recombinant cells and microorganisms of the phylum Labyrinthulomycota and their use in heterologous protein production. Novel promoter, terminator, and signal sequences for efficient production and, optionally, secretion of polypeptides from recombinant host cells and microorganisms are also encompassed by the present invention.

Protein production in microorganisms of the phylum labyrinthulomycota

This disclosure concerns a novel modular docosahexaenoic acid (DHA) synthase and recombinant host organisms genetically modified with such synthase and one or more accessory proteins that allow for and/or improve the production of PUFAs in the host organism. The disclosure also concerns methods of making and using such organisms as well as products obtained from such organisms.

Production of polyunsaturated fatty acids (PUFAs) using a novel modular docosahexaenoic acid (DHA) synthase

Polypeptide for improving protein production in microorganisms of the phylum Labyrinthulomycota

Polynucleotide for improving protein production in microorganisms of the phylum labyrinthulomycota

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Cooksville, MD, United States of America

Jun Wang