New York University

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Memorial Sloan Kettering Cancer Center

Jun R Huh

Dan R Littman

Wenwei Huang

Ruili Huang

Erika Elaine Englund

David Y Gin

Michael Fischbach

Nicolas Gabriel Albert Manel

Michael R Krout

Daniel A Ryan

Steroid compounds are disclosed that have a formula represented by the following: (I) and wherein R, R, R, R, R, R, R, R, R, R, R, and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for promoting differentiation of T regulatory (Treg) lymphocytes, and for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, and graft-versus-host disease.

Steroid compounds as Treg modulators and uses thereof

Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R, R, R, R, R, R, and Rare as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Amido compounds as ROR&#x3b3;t modulators and uses thereof

Methods are presented herein for reducing the risk of developing a psychiatric disorder (e.g., autism like disorder) in a fetus involving administering an inhibitor of T helper 17 (Th17) cell activity to the mother of the fetus, while the mother is pregnant with the fetus at risk. Also encompassed herein is a method for treating a fetus in utero to reduce the risk of abnormal cortical development that arises from Th17 cell-mediated activity.

Maternal TH17 cells and psychiatric disorders

Amido compounds are disclosed that have a formula represented by the following: and wherein Cy, Cy, n1, n2, R, R, R, R, R, R, and Rare as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R, R, R, R, R, R, R, R, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Steroid compounds as RORyt modulators and uses thereof

Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as ROR&#x3b3;t modulators that have a formula represented by the following: and wherein n1, n2, R, R, R, and Rare as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Growing community of inventors

Newton, MA, United States of America

Jun R Huh