The Broad Institute, Inc.

Massachusetts Institute of Technology

Beth Israel Deaconess Medical Center, Inc.

Whitehead Institute for Biomedical Research

Jun Pu

Benito Munoz

Timothy A Lewis

Eamon Comer

Nobutaka Kato

Jeremy Duvall

Christina Scherer

Bertrand Braibant

Jennifer A Beaudoin

Matthew Leighty

Jessica Bastien

Morgane Sayes

Sivaraman Dandapani

Stephen L Buchwald

Susan Lindquist

Partha Pratim Nag

Robert Flaumenhaft

Jean-Baptiste Langlois

Benjamin Vincent

Chris Dockendorff

Willmen Youngsaye

Luke Whitesell

Tatiana Pilyugina

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria.

Compounds and methods for the treatment of malaria

The invention provides compounds of formula (I) that inhibit PDI, for use in methods to treat or prevent a disease or condition in a subject that would benefit by inhibition of PDI. Formula (I) 

Compounds for use in methods for treating diseases or conditions mediated by protein disulfide isomerase

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of malaria. 

The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrate, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive Compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoan, or inhibiting the growth of a fungus or protozoan. The fungus may be aspecies,species, or other pathogenic fungal species. The compounds of the invention may inhibit the activity of fungal or protozoan mitochondrial phosphate carrier protein.

Thiohydantoin derivatives and uses thereof

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Cambridge, MA, United States of America

Jun Pu