Sankyo Company, Limited

The Uab Research Foundation (the University of Alabama at Birmingham)

Kyoto Pharmaceutical Industries, Ltd.

Jun Ohsumi

Kimihisa Ichikawa

Tong Zhou

Donald J Buchsbaum

Robert P Kimberly

William J Koopman

Albert F LoBuglio

Yo Takiguchi

Ichiro Kawashima

Hidehiko Furukawa

Tokio Tani

Toshinori Ohmine

Tohru Takahashi

Nobufusa Serizawa

Yasuo Shimoji

Kazuhiko Sasagawa

Hideyuki Haruyama

Hiroko Yoshida

Kazushi Araki

Akio Shiraishi

Shin Yonehara

Makoto Yachi

Masahiko Ohtsuki

Albert F Lobuglio

An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Combinations of antibodies selective for DR5 and other therapeutic agents

The present invention provides a screening method for a compound which is highly safe and has a prophylactic or therapeutic effect on diabetes, and a highly safe pharmaceutical composition for the prophylaxis or treatment of diabetes. Specifically, a drug for the prophylaxis or treatment of diabetes, which contains, as an active ingredient, a compound having PPAR&#x3b3; activation activity and PTP inhibitory activity, and a method of screening for the drug are provided.

Insulin resistance curative and method of screening the same

Combinations of DR5 antibodies and other therapeutic agents

Anti-Fas antibodies which are cross-reactive with mouse and human Fas and are useful in the treatment of conditions attributable to abnormalities in the Fas/Fas ligand system.

Anti-Fas antibodies

Human pancreatic elastase can now be obtained from a genetically engineered source.

Human pancreatic elastase

Compounds of formula (I): ##STR1## and pharmaceutically acceptable salts thereof are valuable in the treatment of cachexia.

Method of treating cachexia

Growing community of inventors

Kanagawa-ken, Japan

Jun Ohsumi