Wakunaga Seiyaku Kabushiki Kaisha

Jun Nomiyama

Masaharu Yokomoto

Akira Yazaki

Satoshi Inoue

Hirotaka Amano

Terukage Hirata

Nobuya Sakae

Takashi Yatsunami

Koichi Tamura

Masayasu Okuhira

Shuichiro Noda

Hitoshi Yamamoto

This invention relates to a biphenylmethane derivative represented by the formula (1): ##STR1## wherein A represents a group ##STR2## in which R.sup.1, X, Y, Z and B are as defined in the Specification. The compounds have potent angiotensin II antagonist activity and anti-hypertensive effect. They have therapeutic utility for circulatory diseases such as hypertension, heart diseases and cerebral apoplexy.

Biphenylmethane derivatives and pharmaceuticals containing the same

Isoindoline derivatives represented by the formula (I) and their salts are disclosed. ##STR1## There are many varieties for the compound depending on the types of residues R.sup.1 -R.sup.9 and X. The compounds can be prepared from quinoline derivatives of the formula (II) and an isoindoline derivatives of the formula (III). The compounds of formula (I) and their salts have excellent antibacterial activities against both gram positive and gram negative microorganisms. They can be used as a medicine, an agrichemical, and a food preservative.

Isoindoline derivative

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Hiroshima, Japan

Jun Nomiyama