Boehringer Mannheim Gmbh

The Noguchi Institute

La Jolla Cancer Research Foundation

Burnham Institute for Medical Research

La Jolla Cancer Research Foun.

Jun Nakayama

Minoru Fukuda

Rita Gerardy-Schahn

Matthias Eckhardt

Takashi Shirai

Masaya Fujita

Takashi Yamanoi

Masako Mori

Masatomo Kawakubo

Tsutomu Katsuyama

A method for directly inhibiting proliferation ofbacteria, that includes administering to a subject infected withan N-acetylglucosaminyl beta-linked monosaccharide represented by:GlcNAcl-beta-O&#x2014;Ywhere Y is an alkyl group, an alkoxyl group, an alkenyl group, an alkynyl group, an aralkyl group, an aryl group, a heteroaryl group, a carboxyl group, or an alkoxycarbonyl group.

[object Object]

A method for inhibiting proliferation ofincluding a compound that can simply be mass-produced, can specifically inhibit the proliferation of, which has high safety and never generates any resistant bacteria, as well as a diet of a food or beverage, and a pharmaceutical preparation containing the proliferation inhibitor of. The proliferation inhibitor ofcomprises an alpha-N-acetyl-glucosaminyl bond-containing monosaccharide derivative represented by the following chemical formula (1)GlcNAc1-alpha-O&#x2014;Y &#x2003;&#x2003;(1)(in the formula (1), Y is a straight-, branched- or cyclic-aliphatic hydrocarbon group having 1 to 27 carbon atoms or a straight-, branched- or cyclic-acyl group having 1 to 27 carbon atoms). The diet of the food, the beverage or the pharmaceutical preparation comprises the proliferation inhibitor of

Proliferation inhibitor of helicobacter pylori including alpha-n-acetyl-glucosaminyl bond-containing monosaccharide derivatives

Compositions useful for inhibiting the growth of bacteria, including bacteria that can cause gastric ulcers, are provided. In addition, transgenic organism that can produce such compositions are provided. Methods of using the compositions to treat or prevent gastric ulcers in a subject, including a human subject, also are provided.

Antimicrobial carbohydrates and methods of using same

A protein having polysialyl transferase activity, which a) is a product of a prokaryotic or eukaryotic expression of an exogenous DNA, b) is coded by the DNA sequence shown in SEQ ID No. 1, c) is coded by the DNA sequences which hybridize with the sequences SEQ ID No. 1 and/or SEQ ID No. 3, d) is coded by DNA sequences which if there was no degeneracy of the genetic code, would hybridize with the sequences defined in b) to c), and e) catalyzes the polycondensation of .alpha.-2,8-linked sialic acids, and its related nucleic acid molecules and fragments are useful for the production of therapeutic agents for tumor therapy.

Isolated nucleic acid molecules which encode mammalian or rodent 2,8

Isolated nucleic acid molecules encoding polysialyl transferases, and the polysialyl transferases themselves are disclosed. SEQ ID NOS: 1, 2, 7 and 8 present examples of these. The nucleic acid molecules and the proteins can be used diagnostically or therapeutically. Additionally, antisense oligonucleotides and antibodies are described, which can also be used diagnostically or therapeutically.

Isolated polysialyl transferases

Isolated nucleic acid molecules which hybridize to polysialyl

Isolated nucleic acid molecules which encode mammalian .alpha.2,8

Growing community of inventors

Matsumoto, Japan

Jun Nakayama