Ajinomoto Co., Ltd.

Fuji Electric Co., Ltd.

Mitsubishi Chemical Corporation

Jun Nakamura

Hisao Ito

Seiko Hirano

Hiroyuki Kojima

Tsuyoshi Nakamatsu

Keita Fukui

Osamu Kurahashi

Kazuhiko Matsui

Hiroshi Izui

Eiichiro Kimura

Sohei Kanno

Kenji Yamagishi

Yoko Asakura

Tsuyoshi Ohsumi

Mikiko Suga

Makoto Murase

Chie Koseki

Ryusuke Aoyama

Hisashi Yasueda

Yoshihiko Hara

Mika Moriya

Kenichi Hashiguchi

Hiroki Kawashima

Akito Chinen

Masamichi Iwasaki

Yumi Matsuzaki

Masaaki Ajima

Ranko Nishi

Shuichi Yunomura

Mikiko Yamaguchi

Yasuhiro Yokoyama

Takeshi Nagahiko

Kayo Moriguchi

Hiromi Ohtaki

Miki Ikuta

Kayo Akiyama

Madoka Yonekura

Sanae Sato

Akiko Sakamoto

A finned tube heat exchanger includes a plurality of tube arrays, each of which includes a plurality of heat transfer tubes that each extend parallel to one another and are disposed at a predetermined pitch in a first direction that intersects a flow direction of heat exchanging air, in a second direction that intersects the first direction, any closest two of the plurality of tube arrays having a predetermined distance therebetween. One closest two tube arrays includes first and second tube arrays that respectively include a plurality of first heat transfer tubes and a plurality of second heat transfer tubes. When seen from the flow direction, each first heat transfer tube is disposed closer to one of an adjacent two second heat transfer tubes that is closest to said each first heat transfer tube, than to the other one of the adjacent two second heat transfer tubes.

Finned tube heat exchanger

Coryneform bacteria are described that have an ability to produce L-amino acids and are modified so that acetyl-CoA hydrolase activity is decreased. The bacteria are used to produce L-amino acids generated by a biosynthetic pathway in which pyruvic acid is an intermediate, such as L-glutamic acid, L-arginine, L-glutamine, L-proline, L-alanine, L-valine, and L-lysine.

L-amino acid-producing bacterium and a method for producing L-amino acid

A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic acid is collected from the medium or cells.

L-glutamic acid-producing microorganism and a method for producing L-glutamic acid

A method for producing L-glutamic acid by culturing a coryneform bacterium in which the gluX is inactivated in a medium to produce L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium.

L-glutamic acid-producing bacterium and method for production of L-glutamic acid

A microorganism which has an L-amino acid producing ability and has been modified so that succinate dehydrogenase activity and &#x3b1;-ketoglutarate dehydrogenase activity are decreased is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorganism, and the L-amino acid is collected from the medium or cells to produce the L-amino acid.

Method for producing an L-amino acid

L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, and L-cysteine are produced by culturing in a medium a bacterium having an L-amino acid-producing ability and wherein the bacterium has been modified so that the phosphotransacetylase activity is enhanced.

Method for producing L-amino acid

Provided is a bacterium which is capable of producing an organic acid and is modified so as to have an enhanced 2-oxoglutarate dehydrogenase activity as compared with that of an unmodified strain. An organic acid such as succinic acid can be produced by culturing the bacterium.

Bacterium having enhanced 2-oxoglutarate dehydrogenase activity

Coryneform bacterium is modified so that an activity of acetyl-CoA hydrolase is decreased, and succinic acid is produced by using the bacterium.

Succinic acid-producing bacterium and process for producing succinic acid

L-glutamine is produced by culturing a coryneform bacterium having L-glutamine-producing ability and modified so that intracellular glutaminase activity is reduced, and preferably also modified so that intracellular glutamine synthetase activity is enhanced. The method of production includes culturing the bacterium in a medium, followed by accumulation of L-glutamine in the medium and collecting the L-glutamine from the medium.

Method for producing L-glutamine and L-glutamine producing bacterium

A method for producing L-glutamic acid by culturing a coryneform bacterium which has L-glutamic acid producing ability and which has been modified so that expression of the fasR gene is enhanced in a medium to produce and accumulate L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium or cells.

L-glutamic acid producing bacterium and a method for production of L-glutamic acid

Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product produced by any treatment of the bacterium with an organic raw material in a reaction solution containing a carbonate ion, a bicarbonate ion or carbon dioxide gas to thereby yield the desired succinic acid.

Process for production of succinic acid

Succinic acid is produced by allowing a bacterium modified to enhance fumarate reductase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. More preferably, succinic acid is produced by allowing a bacterium modified to enhance activities of fumarate reductase and pyruvate carboxylase and decrease lactate dehydrogenase activity or cell preparation thereof to react with an organic raw material in a reaction solution containing one of a carbonate ion, a bicarbonate ion, and carbon dioxide gas to generate succinic acid. Succinic acid is obtained by collecting the produced succinic acid.

Method of producing succinic acid with bacterium comprising a modified fumarate reductase gene or a modified succinate dehydrogenase gene

A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium so that it is close to a consensus sequence or introducing a change in the promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on the chromosome of a coryneform bacterium by gene recombination so that it is close to a consensus sequence, obtaining mutants of the coryneform amino acid- or nucleic acid-producing microorganism, culturing the mutants and select a mutant capable of producing the intended amino acid or nucleic acid in a large amount. This method allows one of skill in the art to construct a mutant capable of enriching or controlling the expression of an intended gene without using a plasmid and to promote production of amino acids in a high yield, by the recombination or mutation.

Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains

Growing community of inventors

Kawasaki, Japan

Jun Nakamura