Mitsubishi Tanabe Pharma Corporation

Jun Murakami

Takayuki Kawaguchi

Toru Iijima

Hidenori Akatsuka

Tatsuya Watanabe

Takashi Mitsui

Masamichi Morimoto

Yasunori Tsuboi

The present invention provides a condensed furan compound of the formula (I): wherein Ring X is benzene, pyridine, or the like; Y is an optionally substituted amino, an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted saturated heterocyclic group, an optionally substituted unsaturated heterocyclic group; A is a single bond, lower alkylene, lower alkenylidene, lower alkenylene or an oxygen atom; Ris hydrogen or the like; and, Ris hydrogen, or the like, or pharmaceutically acceptable salts thereof, which is useful as a medicament, particularly, as an activated blood coagulation factor X inhibitor.

Condensed furan compounds

The present invention provides a carbamoyl-type benzofuran derivative of the formula [1]: wherein Ring Z is a group of the formula: etc.; A is a single bond, and the like; Y is a cycloalkanediyl group, etc.; Rand Rare the same or different and each is an optionally substituted lower alkyl group, etc.; Ris a halogen atom, etc.; Ring B of the formula: is an optionally substituted benzene ring; and Ris a hydrogen atom. etc., or a pharmaceutically acceptable salt thereof, which is useful as an FXa inhibitor.

Carbamoyl-type benzofuran derivatives

The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: &#x2014;N&#x2550; or &#x2014;CH&#x2550;; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; Ris a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and Ris a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.

Benzofuran derivative

Fused furan compound

The present invention provides an amide-type carboxamide derivative of the formula [1]: wherein X is a group of the formula: &#x2014;N&#x2550; or the formula: &#x2014;CH&#x2550;; Ris a halogen atom, a lower alkyl group, and the like; Ris a group of the formula: and the like; Yand Yare the same or different and each is a group selected from a halogen atom, a lower alkyl group, a lower alkoxy group, and the like; Ring A is phenyl group, and the like, or a pharmaceutically acceptable salt thereof, which is useful as an inhibitor of FXa.

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Saitama, Japan

Jun Murakami