Cell Signaling Technology, Inc.

Jun-Ming Cai

Ailan Guo

Michael Comb

John Edward Rush, Ii

Jing Zhou

Jing Li

Ting-Lei Gu

Jian Yu

Herbert Haack

Victoria McGuinness Rimkunas

Jiong Wu

Susan Kane

James Wieler

There is provided a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) at least one sumoylated lysine residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said sumoylated lysine residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs. Also provided is a motif-specific, context-independent antibody that specifically binds a recurring, modified motif consisting of (i) a C-terminal aspartic acid residue, and (ii) one or more degenerate amino acids bound by a peptide bond to said C-terminal aspartic acid residue, said antibody specifically binding said motif in a plurality of non-homologous peptides or proteins within an organism in which it recurs.

Motif-specific and context-independent antibodies that specifically bind to a sumoylated lysine-containing residue

The invention discloses binding agents to the E746-A750 deletion and the L858R point mutations in the epidermal growth factor receptor (EGFR) molecule, and methods for use thereof, including methods for the diagnosis and treatment of cancer.

Compositions and methods for detecting EGFR in cancer

Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif

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South Hamilton, MA, United States of America

Jun-Ming Cai