Shanghai Tianma Am-oled Co., Ltd.

Genor Biopharma Co., Ltd.

Medshine Discovery Inc.

Shanghai Institute of Pharmaceutical Industry

Guangxi University

Visualon, Inc.

Guangdong Zhongsheng Pharmaceutical Co., Ltd

China State Institute of Pharmaceutical Industry

Shanghai Rebone Biomaterials Co., Ltd.

Guangxi Junfuhuang Ground Source Heat Pump Co., Ltd

Jun Lin

Jinghua Niu

Xiangcheng Wang

Shuang Cheng

Qing Zhu

Lei Wen

Shuhui Chen

Ping An

Changqing Wei

Honghu Ma

Chen Zhang

Jian Li

Jun Wang

Hao Wu

Bin Zhou

Zhi Zhang

Wenyuan Qian

Chaofeng Long

Xiaoxin Chen

Zhuowei Liu

Zhen Gong

Chin-Yee Lin

Yuan Yuan

Quanhai Liu

Lijuan Chen

Yinhe Liu

Joe Zhou

Yonggang Liao

Qing Zhou

Shaoxiong Wang

Weili Qiao

Jianyun Wang

Yongzhi Shu

Xiaoqian Sun

Xiaoxi Na

Chaonan Liu

Yunhui Li

Jiafa Huang

Haifeng Hu

Jiangchao Qian

Chengyong Wang

Yingning Hu

Changshen Liu

Xinxing Ma

Jiuru Sun

Jianyang Zhao

Baoquan Zhu

Zhuzi He

Mengjun Shu

Biao Li

Disclosed is to a thiadiazole derivative and the uses thereof in preparing a drug for treating GLS1-associated diseases. Specifically disclosed is a derivative compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof. 

Substituted 1,3,4-thiadiazoles as GLS1 inhibitors

Provided are an organic light-emitting display panel and a display device, for improving the light extraction efficiency of OLED display panel. The organic light-emitting display panel includes an array substrate having a plurality of driving elements, and a plurality of organic light-emitting components. Each light-emitting component includes an anode, a cathode and an organic functional layer arranged between the anode and the cathode. The organic functional layer includes a hole transmission region, a light-emitting layer, and an electron transmission region stacked in a sequence from the anode to the cathode. With respect to visible light having a certain wavelength, a refractive index of the light-emitting layer is less than a refractive index of the electron transmission region, and the refractive index of the light-emitting layer is less than a refractive index of the hole transmission region. The above organic light-emitting display panel is applicable to the display device.

Organic light-emitting display panel and display device

Provided are a display panel, a display device and a display method of the display panel. The display panel includes a pixel array, where the pixel array includes a plurality of pixel groups and each of the plurality of pixels group includes first-type pixel units and second-type pixel units; and a drive circuit configured to provide a drive signal for the pixel array. A display mode of the display panel includes a high-definition display mode in which within one-frame time, the first-type pixel units and the second-type pixel units collectively display a same to-be-displayed picture; a stereoscopic display mode in which the first-type pixel units display a user's left-eye picture within first time and the second-type pixel units display a user's right-eye picture within second time; and a power saving display mode in which the first-type pixel units display a picture and the second-type pixel units do not perform displaying.

Display panel, display device and display method of display panel

A heat pump system includes a main heat pump system, a heat retaining layer and a reflecting layer coated on an partial inner surface of a building, a directly expanded strong cool-heat radiation plate having a distance from the reflecting layer, a heat radiating layer located at a side of the directly expanded strong cool-heat radiation plate and having a distance from the directly expanded strong cool-heat radiation plate, a buffer plate disposed between the heat radiating layer and the directly expanded strong cool-heat radiation plate, an anti-condensation trough disposed below the directly expanded strong cool-heat radiation plate. A sealed cavity is enclosed by the heat radiating layer and a wall surface, and the wall surface is formed by a combination of the partial inner surface of the building, the heat retaining layer and the reflecting layer, and, the sealed cavity is filled with air.

Heat pump system and air-conditioner

Organic light-emitting display panel and device are provided for improving performance of the organic light-emitting device. The organic functional layer comprises an organic light-emitting layer and a first electron transmission layer between the cathode and the organic light-emitting layer. The first electron transmission layer comprises a first doping agent, and the first doping agent contains alkaline earth metal elements or rare earth metal elements. A second electron transmission layer is located between the first electron transmission layer and the organic light-emitting layer, and the second electron transmission layer is undoped with the first doping agent. A lowest unoccupied molecular orbital LUMO1 in the first electron transmission layer and a lowest unoccupied molecular orbital LUMO2 in the second electron transmission layer satisfy: |LUMO1&#x2212;LUMO2|&#x3c;0.18 eV. A highest occupied molecular orbital HOMO2 in the second electron transmission layer and a highest occupied molecular orbital HOMO3 of the organic light-emitting layer satisfy: |HOMO2&#x2212;HOMO3|&#x3c;1 eV.

Provided are a display panel, a manufacturing method thereof and a display device. The display panel includes: a first substrate and a second substrate disposed opposite to each other, and a plurality of light-emitting units and a plurality of fingerprint identification units, disposed on one side of the first substrate facing to the second substrate. Each of the plurality of light-emitting units includes a first N-type semiconductor layer and a first P-type semiconductor layer, each of the plurality of fingerprint identification units includes a second N-type semiconductor layer and a second P-type semiconductor layer. The first N-type semiconductor layer and the second N-type semiconductor layer are disposed in a same layer, and the first P-type semiconductor layer and the second P-type semiconductor layer are disposed in a same layer.

Display panel, manufacturing method thereof and display device

Provided are an organic light-emitting display panel and a display device. The organic light-emitting display includes an array substrate and organic light-emitting components each having anode, cathode and organic functional layer. The organic functional layer includes an organic light-emitting layer, a first and second electron transmission layer and an electron injection layer. The first electron transmission layer and electron injection layer include a first dopant containing an alkaline earth metal element or a rare earth metal element. A work function &#x3c6;1 of the electron injection layer and a work function &#x3c6;2 of the cathode satisfy: &#x3c6;1&#x3c;&#x3c6;2, and the work function &#x3c6;1 of the electron injection layer and a work function &#x3c6;3 of the first dopant satisfy: &#x3c6;1&#x2265;&#x3c6;3. LUMO1 and LUMO2 satisfy: |LUMO1&#x2212;LUMO2|&#x3c;0.18 eV.

The present invention provides a mutated antibody of the fully humanized HER2 antibody GB235-019, wherein the amino acid sequence of the heavy chain variable region and the amino acid sequence of the light chain variable region of the mutated antibody are respectively SEQ ID NO: 10, SEQ ID NO: 2; SEQ ID NO: 11, SEQ ID NO: 2; or SEQ ID NO: 12, SEQ ID NO: 2. The mutated antibody has the ability to specifically bind to human HER2 antigen, similar to the GB235-019 antibody. They can also be used in combination with additional HER2 positive tumor therapeutic agents for treating HER2 positive tumor, weakly positive tumor or negative tumor.

Mutated antibody of fully humanized HER2 antibody, and encoding gene and use thereof

Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating diseases relating to hedgehog pathway including cancer.

Quinoline derivatives as SMO inhibitors

Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity. 

Platinum (II) compound, preparation method therefor, and pharmaceutical composition and application thereof

A system for controlling executable size of video development kits comprises an SDK. The SDK comprises a framework, an SDK library function, and a pointing function to deliver a pointer. The framework calls a pointing function. The SDK library function comprises a video processing function. The framework and the SDK library function are compiled into a video processing application. The pointing function points to the SDK library function. The pointing function includes a preprocessor conditional to remove a code section that refers to the SDK library function.

System for video development kits with control of executable size

The disclosure provides a novel anti-angiogenesis fusion protein. The present invention combines a chimeric vascular endothelial cell growth factor (VEGF) receptor or a fragment thereof with a multimerizing component, which have a superior binding capacity with human VEGF and placental growth factor (PIGF). The fusion protein has improved stability, prolonged half-life and the ability to form multivalent interactions with VEGF, and can be used for anti-angiogenesis, treating VEGF related diseases and inhibiting tumor growth.

Anti-angiogenesis fusion proteins

The invention discloses an optimized DNA sequence of recombinant human bone morphogenetic protein-2 (rhBMP-2) based on theexpression system and a method for the preparation of the rhBMP-2. Specifically, the invention provides the optimal DNA sequences suitable forexpression system, the methods for efficient preparation of the rhBMP-2, and the related construction of the recombinant bacteria, the expression and purification technologies. Compared with the traditional hBMP-2 gene without optimizing, the rhBMP-2 expression level of the optimized gene inis increased by 50%. Additionally, this invention also provides a method for preparation long chain rhBMP-2 with enhanced renaturation efficiency and yield of purification.

Optimized DNA sequences encoding recombinant human bone morphogenetic protein-2 (rhBMP-2), preparation method and the uses thereof

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Shanghai, China

Jun Lin