Florida International University

Hercules Corporation

Jun Li

Barry P Rosen

Masafumi Yoshinaga

Robert G Nickol

George Wang

H N Cheng

Guodong Niu

The subject invention provides arsinothricin (AST) or salts thereof, and compositions comprising AST or a salt thereof for use as multi-stage antimalarials. The subject invention also provides methods for treating, inhibiting and/or preventing malaria infection and transmission by using AST or salts thereof, or compositions comprising AST or a salt thereof. Advantageously, AST or a salt thereof inhibits glutamine synthetase (GS) of malaria pathogens without exhibiting cytotoxicity to human host.

Arsinothricin as a multi-stage antimalarial

The invention pertains to methods and vaccines suitable for preventing or reducing malaria transmission. The vaccines block the interaction between &#x3b1;-tubulin from a malarial parasite and FREP-1 from the mid-gut of a malaria carrier mosquito, for example,

Vaccines against malaria transmission

Galactosylated hydroxyalkyl polysaccharides wherein galactose moieties are bound to the hydroxyalkyl polysaccharide by galactosidic bonds, and a process for preparing the galactosylated hydroxyalkyl polysaccharides having the steps: a) providing at least one hydroxyalkyl polysaccharide; and b) treating said hydroxyalkyl polysaccharide with a galactose donor in the presence of galactosidase enzyme for a time sufficient to convert at least a portion of said hydroxyl groups to galactosides.

Galactosylated hydroxyalkyl polysaccharides

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Miami, FL, United States of America

Jun Li