Cornell University

The University of Texas System

Jun Kameoka

Harold G Craighead

Gerard L Coté

Mitchell B Robinson

Po-Jung Huang

Haley L Marks

Mien-Chie Hung

Nan Jing

Chao-Kai Chou

Keiyo Nakano

Onder Dincel

Ting-Yen Chi

A system for providing an indication of the presence of molecular structures in a medium is provided. The system includes a radio frequency (RF) wireless antenna, batteryless sensor, and a network analyzer. The sensor has an ultra-high frequency dipole antenna that transmits data to the RF wireless antenna and a sensing element. The sensing element is operatively coupled to the dipolar antenna and detects the presence of molecular structures. When molecular structures are detected, data indicative of the presence of the molecular structures is transmitted to a radio frequency (RF) wireless communication antenna from the dipole antenna. The network analyzer receives the data from the RF wireless antenna and analyzes the data to determine a concentration of molecular structures.

Low cost and wireless gas sensing paper sensor having UHF range

There is a need in the point-of-care diagnostic community for an efficient and portable method for testing blood and other biological fluids that can be easily translated across multiple applications. An aspect of the invention described involves monitoring the optical properties of molecularly-mediated nanoparticle assemblies though an optically transparent and magnetically active microfluidic chip, which has recently emerged as an attractive method for biomarker detection as it is an efficient tool for monitoring the binding events that take place in a sensing assay. In one embodiment, this device is directed towards two-nanoparticle assays that rely on the assembly or disassembly of plasmonic and magnetic nanoparticles in response to a certain analyte. A further embodiment is directed to a spiral microfluidic using inertial forces to filter fluid components by size, connected to a magnetically active channel comprised of a nickel micropad array, optically transparent microchannel, and permanent magnets.

Device for spectroscopic detection and monitoring of biologically relevant molecules

Nanofibers are formed using electrospray deposition from microfluidic source. The source is brought close to a surface, and scanned in one embodiment to form oriented or patterned fibers. In one embodiment, the surface has features, such as trenches on a silicon wafer. In further embodiments, the surface is rotated to form patterned nanofibers, such as polymer nanofibers. The nanofibers may be used as a mask to create features, and as a sacrificial layer to create nanochannels.

Scanned source oriented nanofiber formation

A single molecule or molecule complex detection method is disclosed in certain aspects, comprising nano- or micro-fluidic channels.

Methods for detecting molecule-molecule interactions with a single detection channel

A nanofiber membrane is formed on a microfiber membrane. The nanofiber membrane may be electro sprayed directly onto the microfiber membrane and becomes integrated with the microfiber membrane to form a filter. The microfiber membrane provides structural integrity to for the nanofiber membrane, and an additional microfiber membrane may be added to sandwich the nanofiber membrane.

Microfiber supported nanofiber membrane

A system and method for detecting changes in the refractive index of a fluid in a small test volume. A change in the refractive index can indicate a change in the chemical composition of the fluid. The test volume has a depth comparable to or less than the wavelength of incident light. In one embodiment, an internal surface of the volume is coated with a binding partner selected to bind with a targeted molecule. When the targeted molecule binds to the binding partner, the optical properties of the system change. The refractive index is determined by illuminating the test volume with laser light and measuring transmitted or reflected light.

Nanofabricated photon tunneling based sensor

An electrospray ionization device incorporates a shaped thin film with a microfluidic channel. The device may be interfaced to a time-of-flight mass spectrometer (TFOMS). In one embodiment, the shaped thin film has a polygonal-shaped or triangle-shaped thin polymer tip formed by lithography and etching. The microfluidic channel is approximately 20 micrometer wide and 10 micrometers deep, and embossed in a substrate using a silicon master. The shaped thin film is aligned with the channel and bonded between the channel substrate and a flat plate to create a microfluidic channel with a wicking tip protruding from the end of the channel. Application of a high voltage at one end of the channel creates an electrospray from the tip, which is provided to the TFOMS.

Growing community of inventors

College Station, TX, United States of America

Jun Kameoka