Taipei Medical University

Tlc Biopharmaceuticals, Inc.

Taiwan Liposome Company, Ltd.

Jun-Jen Liu

Keelung Hong

Yun-Long Tseng

Luke S S Guo

Ming-Thau Sheu

Hua-Jing Jhan

Yuan Soon Ho

Chi-Chun Lai

Hsiu-O Ho

Shing Chuan Shen

The invention develops a developed a thermosensitive injectable hydrogel based on HA and a copolymer of polyethylene oxide (PEO) and polypropylene oxide (PPO), which has a gel formation temperature from 30&#xb0; C. to 37&#xb0; C. The thermosensitive injectable hydrogel of the invention provides a potential drug delivery system that can increase therapeutic efficacy of the drug.

Thermosensitive injectable hydrogel for drug delivery

The invention provides a liposome composition for delivering high pay-load of a therapeutic agent to neovascularization sites of the eyes in a patient in need thereof. The liposome composition for entrapping the therapeutic agent comprises a particle forming component composed of a variety of vesicle-forming lipids, and an agent-carrying component able to form a complex with the therapeutic agent via electrostatic charge-charge interaction or hydrophobic-hydrophobic interaction; wherein the liposome composition comprising the therapeutic agent has a mean particle diameter of about 30 to 200 nm and may accumulate at the neovascularization sites of the eyes 24 hours after the intravenous administration of the liposome composition comprising the therapeutic agent to the patient. A method for delivering the therapeutic agent to the eyes in a patient with this liposome composition is also provided.

Liposome composition for delivery of a therapeutic agent to eyes

Growing community of inventors

Taipei, Taiwan

Jun-Jen Liu