Yoshitomi Pharmaceutical Industries, Ltd.

Konishi Co., Ltd.

Jun Inui

Shinichi Sato

Hideki Ao

Kazuhiko Araki

Minoru Obata

Tadashi Mishina

Tomio Muro

Manabu Hashimoto

Toshio Seki

Masao Abe

Kenichi Aihara

Yukihiro Nomura

Yoshinao Tsuda

Hiroyuki Sato

Hiroyuki Fujimoto

Tadao Nakamura

Takashi Kida

It is provided a method for producing a pressure-sensitive adhesive tape or sheet which is superior in a heat-resistance. A mixture is prepared by uniformly mixing a specific polymer having hydrolyzable silyl end groups and urethane linkages and/or urea linkages in the main chains or side chains with tackifying resins. A fluorine-containing compound selected from the group consisting of boron trifluoride, complex of boron trifluoride, fluorinating agent and alkali metal salt of fluorine-containing inorganic acid is uniformly mixed into the mixture to obtain a precursor of a pressure-sensitive adhesive agent. The adhesive precursor is applied on the surface of a tape substrate or sheet substrate. It is obtained a pressure-sensitive adhesive layer having three-dimensional reticulation structures by curing the specific polymer having hydrolyzable silyl end groups. Thereby, it is obtained the pressure-sensitive adhesive tape or sheet.

Method for producing a pressure-sensitive adhesive tape or sheet

An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

Curing resin, method for producing same and curing resin composition

A trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compound of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are the same or different, and respectively represent hydrogen, C.sub.1-10 alkyl, C.sub.2-5 alkanoyl, formyl, C.sub.1-4 alkoxy-carbonyl, amidino, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkylcarbonyl, phenyl, phenylalkyl, benzoyl, naphthoyl, phenylalkoxycarbonyl, benzylidene, pyridylcarbonyl, piperidyl, pyrrolidylidene or piperidylidene which may be optionally substituted on the ring or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom form 5 to 6-membered cycle which may have oxygen atom, sulfur atom or optionally substituted nitrogen atom in the cycle, or together with the adjacent nitrogen atom form phthalimido, R.sup.3 represents hydrogen or C.sub.1-4 alkyl, R.sup.4 represents hydrogen or C.sub.1-4 alkyl, R.sup.5 represents hydrogen, hydroxy, C.sub.1-4 alkyl or phenylalkoxy. R.sup.6 represents hydrogen or C.sub.1-4 alkyl, A represents single bond, C.sub.1-5 straight chain alkylene, or alkylene which is substituted by C.sub.1-4 alkyl, n represents 0 to 1, an optical isomer thereof and a pharmaceutically acceptable acid addition salt thereof. These compounds possess antihypertensive activity, and coronary, cerebral and kidney circulation-improving activities and are useful as antihypertensive agents and agents for prevention and treatment of circulatory diseases.

Trans-4-amino(alkyl)-1-pyridylcarbamoylcyclohexane compounds and

A polyazaheterocycle compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the specification. Said compounds exhibit calcium antagonistic and/or calcium agonistic activities.

Polyazaheterocycle compounds

A thiadiazine compound of the formula: ##STR1## a method for preparing said compound and a pharmaceutical composition containing said compound, wherein X is methylene which may be optionally substituted by an alkyl of up to 3 carbon atoms; R is hydrogen atom or methyl group; and n is an integer of 1 or 2. Since the compounds exhibit potent cardiotonic and coronary vasodilator activities and further inhibitory activity on platelet aggregation, they are useful as cardiotonic and antithrombotic drugs.

Thiadiazine compounds

1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives of the general formula: ##STR1## or acid addition salts thereof, wherein W is --CH.dbd. or --N.dbd.; Y is --CH.dbd.CH--, --O--, --S--, --CH.dbd.N(O)p-- (p is zero or 1) or --N(R)-- (R is hydrogen or lower alkyl); X.sup.1, X.sup.2 and X.sup.3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkylthio; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent or two or three substituents which may be the same or different, and the substituent may be halogen, lower alkyl, lower alkoxy, lower alkanoylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkylsulfamoyl, amino or di-lower alkylamino); ##STR2## is 5- to 7-membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring, and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or --(CH.sub.2).sub.m --OR.sup.4 (R.sup.4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2); R.sup.1 and R.sup.2 are the same or different, and are each lower alkyl; R.sup.3 is lower alkyl, aralkyl, heteroaralkyl; and n is an integer 1 to 5. Such compounds are useful as antihypertensive agents and as therapeutic agents for cardiac and cerebral circulation disorders.

1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and

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Saitama, Japan

Jun Inui