Olympus Optical Company, Ltd.

Tokyo Medical and Dental University

Olympus Corporation

Fujifilm Corporation

Kumiai Chemical Industry Co., Ltd.

Ihara Chemical Industry Co., Ltd.

Jun Inoue

Shinichi Nakajima

Osamu Inagaki

Johji Inazawa

Toshiyuki Terada

Ken-ichi Kozaki

Tatsuyuki Kawano

Hiroki Shibasaki

Shinsuke Yamamoto

Keiji Toriyabe

Masaaki Komatsu

Kazuhiro Satoh

Hidetoshi Fukuda

Issei Imoto

Daikichi Morohashi

Hirohide Fukazawa

Nobuharu Namikawa

Kazuo Akai

Akira Kasai

The present inventors have found microRNAs which are strongly associated with stabilization of NRF2 in tumors, and an object of the present invention is to provide means for utilizing such miRNAs for the diagnosis and treatment of cancer. The inventors conducted screening of 470 microRNAs in a microRNA library by use of HeLa cells. As a result, 8 miRNAs each exhibiting a large decrease in miRNA activity as compared with a control miRNA, and 8 miRNAs each exhibiting a large increase in miRNA activity as compared with a control miRNA, were identified. The inventors have found that the NRF2 activation in the living body, in particular tumor cells, can be detected by use of the thus-identified miRNAs, whereby malignancy of a tumor, or the like can be differentiated. The inventors have also found that a nucleic acid including a miRNA sequence associated with reduction in the aforementioned ARE activity can be used as a cancer therapeutic agent.

Method for assaying MicroRNA, cancer therapeutic agent, and medical composition containing same for cancer therapy

Method for assaying microRNA, cancer therapeutic agent, and medicinal composition containing same for cancer therapy

To provide a triazole compound which has remarkably excellent pesticidal activities. Optically active (+)-1-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]-5-amino-3-(trifluoromethyl)-1H-1,2,4-triazole represented by the following formula (I), which is obtainable by subjecting a racemic modification of 1-[2-fluoro-4-methyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]-5-amino-3-(trifluoromethyl)-1H-1,2,4-triazole to optical resolution: 

Triazole compound having pesticidal activities

The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.

Method for detecting neuroblastoma

In short, the image processing device for obtaining a single image by using a plurality of image-pickup elements comprises a plurality of image-pickup signal processing circuits that are provided for each of the image-pickup elements, an image arrangement conversion circuit which converts the read-out order of the images corresponding to the respective image-pickup elements that are output from the image-pickup signal processing circuits, an image splitting processing circuit for performing image splitting on the image that is output from the image arrangement conversion circuit, an image processing circuit for performing image processing in parallel on each of the split images, and an image compression circuit for compressing in parallel each of the split images that are output from the image processing circuit.

Image processing device

To provide a camera configured to be supported by the hands of a photographer on the bottom surface of the body thereof whose operability is improved by allowing various settings to be easily made with the camera body supported reliably and allowing a set value to be stored and retrieved with a small number of operation members, a configuration is provided which includes a grip portion protruding in a direction orthogonal to an optical axis of a photographic optical system provided in a predetermined position of a lateral surface of the body of the camera and an operating member for allowing input of information to cause execution of a predetermined operation, the operating member being provided in the vicinity of the grip portion. There is further provided a setting member for setting a desired set value, a set value storing member for storing data representing desired set values which can be set with the setting member in advance, a set value retrieving member for arbitrarily reading the data stored in advance with the set value storing member instead of the set value set with the setting member and for setting a set value based on the same and control unit for controlling the set value storing member and the set value retrieving member such that they can be operated with a single operating member.

Camera

An image pickup apparatus for picking up an object comprises an image pickup device formed by arranging the photoelectric conversion elements constituting pixels in two-dimensional directions. A reading out circuit reads out from the image pickup device an electric signal obtained by photoelectric conversion with the image pickup device. A selecting portion selects from a plurality of reading out modes a reading out mode of the reading out circuit to carry out reading of the electric signal from the image pickup device. A memory circuit stores reading out positions of the image pickup device respectively in correspondence with the plurality of reading out modes. The reading out circuit reads out the electric signals from the image pickup device based on a reading out position corresponding to the reading out mode selected from the plurality of reading out modes by the selecting portion.

Image pickup apparatus capable of reading in optional reading mode

An electronic imaging apparatus composed of a solid-state sensor element for converting an image focused by an optical system into image data. The apparatus is selectively operable in a first drive mode for reading at least a large number of pixels of image data out of the solid-state sensor element, and in a second drive mode for reading a second number of selected pixels of image data out of the solid-state sensor element, the second number being smaller than the large number and the selected pixels being suited for foreground scene recognition. The apparatus further includes an optical black level correction process changing system for changing a process of detecting an optical black level corresponding to an optical black part of the sensor element and correcting image data according to the detected level, the process being changed according to whether the first drive mode or the second mode is selected to effect a first correction in the first drive mode and a second correction in the second drive mode, the first correction being achieved on the basis of a presently detected optical black level, and the second correction being achieved by a feedback control based on a difference between a previously detected optical black level and a desired optical black level.

Electronic imaging apparatus operable in two modes, with a different

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Tokyo, Japan

Jun Inoue