Georgia Tech Research Corporation

Emory University

Jun-Ichiro Hirano

Andreas Sebastian Bommarius

Bettina Bommarius

Jonathan Taejoo Park

Vaijayanthi Thangavel

The present disclosure relates generally to bacterial NADH oxidases and, more particularly, to novel NADH oxidases obtained from, and derivatives thereof that demonstrate enzymatic activity for NADH, NADPH, or both NADH and NADPH. The compositions comprising an NADH oxidase obtained fromor derivatives thereof include: isolated enzymes; recombinantly produced enzymes and derivatives thereof, as well as catalytically active portions thereof; nucleic acids encoding an NADH oxidase obtained from, derivatives thereof, and portions thereof. The methods of the present invention include isolation of NADH oxidases obtained from, derivatives thereof, and portions thereof, and methods for enzymatic reactions comprising NADH oxidase obtained from, including the production of enantiomer-enriched organic compounds.

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Atlanta, GA, United States of America

Jun-Ichiro Hirano