Otsuka Pharmaceutical Company, Limited

Jun-ichi Kunizaki

Makoto Inada

Kazuki Tobita

Tetsuya Sato

Suguru Akamatsu

Hiroshi Motonari

This invention provides a method for measuring insulin resistance of a test subject, and a composition suitably used for the method. A method for measuring insulin resistance of a test act comprising steps (a) and (b) below, the method using a composition for measuring insulin resistance comprising, as an active ingredient, a Cfatty acid labeled with at least one isotope of C, wherein the Cfatty acid is converted in the body into labeled carbon dioxide that is excreted in expired air,

Method of measuring insulin resistance with fatty acid combustion, and composition used herein

A method for measuring energy malnutrition in a liver disease test subject, a method for determining whether a liver disease test subject is in an energy malnutrition state, a method for determining the necessity of nutrition therapy for a liver disease test subject having energy malnutrition, a composition usable in these methods, and the like are provided. The method for measuring energy malnutrition in a liver disease test subject includes the steps of collecting expired air containing labeled carbon dioxide that is generated in the body of a liver disease test subject by being converted from a composition containing, as an active ingredient, glucose labeled with at least one isotope C; and determining the ratio of labeled COamount to unlabeled COamount, or the ratio of labeled COamount to total COamount in expired air.

Energy malnutrition evaluation for liver disease test subject

A method is provided for measuring and evaluating rapidly and with high accuracy a subject's glucose metabolism. The method uses a labeled C-breath test and a composition that is suitably used in the method. The composition contains as active ingredient glucose labeled with at least one isotope of C, wherein the glucose is converted in the subject to labeled carbon dioxide that is excreted in expired air. This method also allows for the determination of a stage of a patient in whom diabetes has developed as well as for a stage before the onset of diabetes, and monitors the state (diabetes condition including a state before onset of diabetes) over time.

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Osaka, Japan

Jun-ichi Kunizaki