Nara Institute of Science and Technology

Rohm Co., Ltd.

University of Michigan

Jx Nippon Mining Metals Corporation

Jun-ichi Kikuchi

Atsushi Ikeda

Yoshihiro Sasaki

Toru Imori

Haruo Kotani

Yoko Hayashi

Thirupathi Ravula

Ayyalusamy Ramamoorthy

Takaaki Shimasaki

Kazuma Yasuhara

Mineo Hashizume

Jin Arakida

Bikash Sahoo

The disclosure generally relates generally to lipid nanodiscs, in particular to lipid nanodiscs formed from acryloyl-based copolymers. A lipid nanodisc according to the disclosure includes a lipid bilayer having a first hydrophilic face and a second hydrophilic face opposing the first hydrophilic face, and a hydrophobic edge between the opposing hydrophilic faces, and an acryloyl-based copolymer encircling the hydrophobic edge of the lipid bilayer. The acryloyl-based copolymer includes a first monomer unit having a pendant hydrophobic group and a second monomer unit having a pendant hydrophilic group. Methods of making and characterizing the lipid nanodiscs are also disclosed.

Lipid nanodisc formation by acryloyl-based copolymers

A metal-coated material comprising a metal-coated lipid bilayer vesicle and a preparation method thereof are provided. A metal-coated material comprising a metal-coated lipid bilayer vesicle having a network of siloxane bonding (Si&#x2014;O&#x2014;Si) on its surface. a method for preparing the metal-coated lipid bilayer vesicle comprising the following steps:

Metal-coated lipid bilayer vesicles and process for producing same

A solution containing a Ccyclodextrin complex and a solution containing a lipid that is capable of forming a liposome are mixed together at a temperature in a range of 10&#xb0; C. to 45&#xb0; C. This produces a C-incorporated liposome which keeps a physical property that the Cfullerene originally has, and is stably solubilized in a polar solvent. Hence, the present invention provides a C-incorporated liposome which keeps a physical property that the Cfullerene originally has, and which is stably solubilized in a polar solvent, a production method of the same, and a use of the same.

C70-containing liposome, method for producing the same, and use of the same

The present invention provides a target recognizing element wherein a receptor is fixed to an inclusion complex containing a mediator. The target recognizing element includes a first host molecule having hydrophilic groups and an inclusion site, a second host molecule having hydrophilic groups and an inclusion site, a receptor which is bonded to the hydrophilic groups of the second host molecule and which reacts with the target, and a guest molecule which is included by the inclusion site of the first host molecule and the inclusion site of the second host molecule and which transfers an electric charge generated by the reaction between the target and the receptor.

Target recognition element and biosensor including the same

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Ikoma, Japan

Jun-ichi Kikuchi