Takeda Pharmaceutical Company Limited

Dot Therapeutics-1, Inc.

Day One Biopharmaceuticals, Inc.

Jun-ichi Kawakami

Masatoshi Yamada

Mitsuhisa Yamano

Yoshiyuki Takeda

Mitsutaka Goto

Masato Kitayama

Sayuri Hirano

Shinji Kawaguchi

Motoki Ikeuchi

Koji Nakamoto

The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale. Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof.

Method for producing optically active compound

The aim of the present invention is to provide a method capable of producing an optically active pyrimidinamide derivative on an industrial scale. Compound (I) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, and the obtained compound (III) or a salt thereof is reacted with compound (VI) or a salt thereof to obtain compound (V) or a salt thereof. wherein each symbol is as defined in the specification.

The present invention provides a novel ligand represented by the following formula and a novel transition metal complex having the ligand, which shows superior enantioselectivity and catalytic efficiency, particularly high catalyst activity, in various asymmetric synthesis reactions. A transition metal complex having, as a ligand, a compound represented by the formula wherein Ris a hydrogen atom or a Calkyl group optionally having substituent(s), and Rand Rare each a Calkyl group optionally having substituent(s), or the formula is a group represented by the formula wherein ring B is a 3- to 8-membered ring optionally having substituent(s).

Diphosphine ligand and transition metal complex using the same

Growing community of inventors

Osaka, Japan

Jun-ichi Kawakami