Santen Pharmaceutical Co., Ltd.

Jun-ichi Iwao

Masayuki Oya

Tadashi Iso

Eishin Kato

Hiroshi Masuda

Toshio Watanabe

Yoichi Kawashima

Takehisa Chiba

Itaru Mita

Takihisa Chiba

Novel benzothiazine derivatives

This invention relates to benzothiazine derivatives represented by the formula [I] and salts thereof, which are useful for treatment of cardiovascular diseases. ##STR1##

Platelet anti-aggregative- and calcium antagonistic

The invention relates to benzothiazoline derivatives of the formula [I] and salts thereof, which are useful for (i) treating cardiovascular diseases, and (ii) as the active ingredient of pharmaceutical compositions. Formula [I] follows: ##STR1## wherein R.sup.1 is lower alkanoyl;

Benzothiazoline compounds which contain a carbonyl group useful for

3-Alkanoyl benzothiazoline compounds useful for treating cardiovascular

Aletheine derivatives of the general formula ##STR1## which are useful for treatment of liver damage.

Aletheine derivatives

This invention relates to novel benzothiazoline derivatives of the formula [I] and salts thereof, ##STR1## wherein R.sup.1 is formyl or lower alkanoyl;

2-Arylbenzothiazoline derivatives and their use in treating angina cordis

Novel S-substituted mercapto-lower alkanoyl-4-thiazolidinecarboxylic acids, -2-pyrrolidinecarboxylic acids and their esters represented by the general formula ##STR1## wherein Q is methylene or sulfur;

Antihypertensive sulfur-containing compounds

Inclusion compounds of cyclodextrin with sulfur-containing compounds

Benzothiazoline compounds

Five-membered heterocyclic compounds

Sulfur-containing acylamino acids

Disulfide compounds which have the general formula ##STR1## and salts thereof used for reducing blood pressure and for preventing or relieving diabetic complications, processes for manufacturing thereof, compositions comprising them and pharmaceutically acceptable excipients, and administering methods are mentioned.

Disulfide compounds

Derivatives of 5-substituted 2-pyrrolidinecarboxylic acid which have the general formula ##STR1## are useful in compositions as antihypertensive agents.

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Takarazuka, Japan

Jun-ichi Iwao