Mitsubishi Tanabe Pharma Corporation

Jun-ichi Endoh

Seigo Ishibuchi

Hidemasa Hikawa

Kazuhiro Maeda

Kunitomo Adachi

Kaoru Tashiro

Akiko Tarao

Minoru Tanaka

Maiko Hamada

Kunio Sugahara

Naoto Fujie

Kouichi Oshita

Meguru Murata

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, or a pharmacologically acceptable salt thereof.

Amide derivative and use thereof as medicine

Provided are a novel low-molecular-weight compound that suppresses production of induction type MMPs, particularly MMP-9, rather than production of hemostatic type MMP-2, as well as a prophylactic/therapeutic drug for autoimmune diseases or osteoarthritis. An amide derivative represented by the following formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, or a hydrate or solvate thereof.

Oxazolidinone amide aromatic compounds for supressing MMP-9 production

A thienotriazolodiazepine compound of the following formula (I) a pharmaceutical agent containing the compound as an active ingredient, and a production intermediate and a production method of the thienotriazolodiazepine compound. Since this compound has an inhibitory action on costimulatory signal from CD28 on T cell, it is useful for the prophylaxis or suppression of rejection reaction in transplantation of organ or bone marrow and the like, and the prophylaxis or treatment of autoimmune diseases or allergic diseases.

Thienotriazolodiazepine compound and medicinal use thereof

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Osaka, Japan

Jun-ichi Endoh