Banyu Pharmaceutical Co. Ltd

Msd K.k.

Jun-ichi Eiki

Teruyuki Nishimura

Tomoharu Iino

Yasuhiro Sasaki

Morihiro Mitsuya

Makoto Bamba

Fumiko Sakai

Keiji Takahashi

Hitomi Watanabe

Noriaki Hashimoto

Toshio Nagase

Yoshio Ogino

Yoshiyuki Sato

Hiroshi Nakashima

Katsumasa Nonoshita

Yasufumi Nagata

Keisuke Arakawa

Chisato Nakama

The present invention relates to a compound which has a glucokinase-activating effect and is useful as a therapeutic agent for diabetes mellitus, being represented by a formula (I): [wherein Xrepresents a nitrogen atom, sulfur atom, oxygen atom or the like; Rrepresents a 6- to 10-membered aryl group, 5- to 7-membered heteroaryl group or the like; D represents an oxygen atom or sulfur atom; Rand Rare the same or different, each representing a hydrogen atom, lower alkyl group or the like; a formula (II) represents an optionally substituted 5- to 7-membered heteroaryl group or the like; a formula (III) represents a monocyclic or bicyclic heteroaryl group] or a pharmaceutically acceptable salt thereof.

2-pyridinecarboxamide derivatives

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: (I) wherein Xto Xindependently represent a carbon atom or the like; the ring A represents a 5- to 6-membered heteroaryl having 1 to 4 heteroatoms independently selected from the group consisting of a nitrogen atom, a sulfur atom and an oxygen atom; Xrepresents an oxygen atom or the like; X represents a carbon atom or the like; Het represents a 5- or 6-membered aliphatic heterocycle; Rrepresents an aryl or the like; Rrepresents a formyl group or the like; and Rrepresents a &#x2014;Calkyl or the like. The compound or salt has a glucokinase activation effect and is useful as a therapeutic agent for diabetes.

Heterocycle-substituted benzimidazole derivative

A glucokinase activator is provided; and a treatment and/or a preventive for diabetes, or a treatment and/or a preventive for diabetes such as retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis, and further a treatment and/or a preventive for obesity are provided. The invention relates to a compound of a formula (I): [wherein Rand Rrepresent a hydrogen, etc.; Rrepresents a hydrogen atom, a halogen atom, etc.; Reach independently represents a hydrogen atom, a lower alkyl group, etc.; Q represents a carbon atom, a nitrogen atom or a sulfur atom (the sulfur atom may be mono- or di-substituted with an oxo group); Rand Reach represent a hydrogen atom, a lower alkyl group, etc.; X, X, Xand Xeach independently represent a carbon atom or a nitrogen atom; Z represents an oxygen atom, a sulfur atom or a nitrogen atom; Ar represents an aryl or heteroaryl group optionally mono to tri-substituted with a group selected from the substituent group &#x3b2;; ring A represents a 5- or 6-membered nitrogen-containing heteroaromatic group; m indicates an integer of from 1 to 6; n indicates an integer of from 0 to 3; p indicates an integer of from 0 to 2 (provided that at least two of Xto Xare carbon atoms); q indicates 0 or 1] or its pharmaceutically-acceptable salt, which has an effect of glucokinase activation and is useful as a treatment for diabetes.

Aryloxy-substituted benzimidazole derivatives

Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): [wherein Xrepresents oxygen, etc., Xrepresents oxygen, etc., Rrepresents a group on Ring A such as alkylsulfonyl, etc., Rrepresents C3-7 cyclic alkyl optionally substituted with a halogen, etc., Rrepresents a substituent on Ring B such as lower alkyl, etc., formula (II):[Chemical Formula 1] represents 6- to 10-membered aryl, etc., and formula (III):[Formula 1] represents monocyclic or bicyclic heteroaryl optionally having on Ring B a substituent represented by Rabove, wherein the carbon atom of Ring B which is bonded to the nitrogen atom of the amide group of formula (I) forms a C&#x2550;N bond with the nitrogen atom of the ring],as well as their pharmaceutically acceptable salts.

Heteroarylcarbamoylbenzene derivatives

The present invention provides a compound having a glucokinase activating action being useful for prevention or treatment of diabetes mellitus, etc. being represented by the formula (I): X is nitrogen atom, etc.; Y is oxygen atom, etc.; Ris an optionally substituted five to six-membered heteroaryl group, etc.; Ris hydrogen atom or fluorine atom; and ring A is a monocyclic or bicyclic heteroaryl group which may have a substituent represented by the formula (II)] or a pharmaceutically acceptable salt thereof.

Substituted quinazoline or pyridopyrimidine derivative

2-pyridine carboxamide derivatives

Compounds represented by formula (I): as well as their pharmaceutically acceptable salts are disclosed. The compounds are useful as glucokinase activating agents for the treatment of diabetes and related conditions. Compositions and methods of treatment are also included.

Heteroarylcarbamoylbenzene derivative

This invention relates to a novel compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, shows a monocyclic or bicyclic heteroaryl group which has a nitrogen atom adjacent to the carbon atom bonded to the amide group, and the heteroaryl group may be substituted by R; The compound according to this invention has a glucokinase activation effect, and for example, is useful in the treatment and prevention of diabetes mellitus, and in the prevention of its complications such as diabetic nephropathy, diabetic retinopathy, diabetic neuropathy and diabetic arteriosclerosis.

Aminobenzamide derivative

Isoindole derivatives

Growing community of inventors

Tsuchiura, Japan

Jun-ichi Eiki