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Kyoto University

Nahls Corporation Co., Ltd.

Jun Hiratake

Ryuzo Yoshioka

Bunta Watanabe

Kanzo Sakata

Hideaki Ishida

Liyou Han

Provided is a method for separating the four optical isomers of Nahlsgen. The method according to the present invention for producing a mixture of a D-2-amino-4-[(Rp)-(3-carboxymethylphenoxy)(methoxy)phosphoryl]butanoic acid hydrate and an L-2-amino-4-[(Sp)-(3-carboxymethylphenoxy)(methoxy)phosphoryl]butanoic acid hydrate includes subjecting a mixture of the four optical isomers, represented by Formula (1'), to fractional crystallization from water or from a solvent mixture of water and a water-soluble organic solvent, to precipitate a mixture of a compound represented by Formula (1-1&#x2032;-1) and a compound represented by Formula (1-4&#x2032;-1), where Formulae (1&#x2032;), (1-1&#x2032;-1), and (1-4&#x2032;-1) are expressed as follows: 

Nahlsgen optical resolution method

A phosphonic acid diester derivative represented by the following general formula (1): 

Phosphonic acid diester derivative and method for producing thereof

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Kyoto, Japan

Jun Hiratake