Guizhou University

Jun He

Mei Chen

Wei Xue

Shijun Su

Shichun Jiang

Ziyou Huai

Jianian Yang

Xu Tang

Ying Chen

Meimei Jin

Liwei Liu

Jichuan Kang

Ming He

Yixin Qian

Yinjiu Huang

Jun Wang

The invention discloses a 4-(N-methyl) aminopiperidine myricetin derivatives containing sulfonamide, a preparation method and application, whose structural general formula is shown as follows: Wherein, R is substituted phenyl and substituted aromatic heterocyclic group; n is the number of carbon in the carbon chain and is 2, 3, 4 and 5 respectively. The substituted phenyl group is an alkyl group containing C1-6, an alkoxy group containing C1-6, a nitro group, a halogen atom or a hydrogen atom in ortho, meta and para positions on the benzene ring. The substituted aromatic heterocyclic group is thienyl, furyl, pyrrolyl, pyridyl, etc., and the substituent on the aromatic heterocyclic ring is an alkyl group containing C1-6, alkoxy group of C1-6, nitro group, halogen atom or hydrogen atom in ortho, meta and para positions. The invention has a better control effect on inhibiting plant germs and can be used as an agricultural bactericide.

Sulfonamide-containing 4-(N-methyl) aminopiperidine myricetin derivatives, preparation method and application

The invention discloses a 4-(N-methyl) aminopiperidine myricetin derivative containing dithiocarbamate, and its preparation method and application, whose structural general formula is shown as follows: wherein R is substituted phenyl and substituted aromatic heterocyclic group; n is the number of carbons in the carbon chain, which are 2, 3, 4 and 5 respectively; the substitute phenyl group is an alkyl group containing C1-6, alkoxy group containing C1-6, nitro group, halogen atom or hydrogen atom in ortho-, meta- and para-position on that benzene ring; the aromatic heterocyclic group is thienyl, furyl, pyrrolyl and pyridyl groups; the substituents on the substituted aromatic heterocycle are o-, m-, and p-containing C1-6 alkyl, C1-6 alkoxy, nitro, halogen, and hydrogen atoms. The invention has better inhibitory activity on cancer cells.

4-(N-methyl) aminopiperidine myricetin derivative containing dithiocarbamate, preparation method and application

Disclosed is a method for separating and purifying Ginkgolide C from root bark of ginkgo. The method comprises: (1) extracting the root bark of ginkgo with ethanol; (2) concentrating the resulting extract under vacuum to remove ethanol; (3) separating the concentrate by macroporous resin column chromatography; (4) after the concentrate being loaded on the column, washing the column with pure water to remove impurities, and then eluting the column with an ethanol solution; (5) concentrating the eluate under vacuum to dryness to obtain a yellow crude extract; (6) heating the crude extract in water to boiling to form a solution, and then refrigerating the solution; (7) concentrating the supernatant solution and filtering under vacuum to obtain a mixed crude crystal of ginkgolides; (8) dissolving the crude crystal in ethanol to form a supersaturated solution, refrigerating and crystallizing the solution to remove Ginkgolides A and B; (9) concentrating and recrystallizing the mother liquor to obtain a crystal of Ginkgolide C; and (10) recrystallizing the crystal with ethanol several times to obtain a high-purity crystal of Ginkgolide C.

Method for separating and purifying Ginkgolide C from root bark of ginkgo

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Guizhou, China

Jun He