Osaka University

Jun Hatazawa

Hayato Ikeda

Yoshiyuki Manabe

Yoshikatsu Kanai

Eku Shimosegawa

Tadashi Watabe

Yoshifumi Shirakami

Kazuko Kaneda

Koichi Fukase

Atsushi Shinohara

Yasukazu Kanai

Zijian Zhang

Atsushi Shimoyama

The invention provides a method for producing a solution containingAt(astatide ion) at a high radiochemical purity by usingAt obtained by a nuclear reaction as a starting material, including a step of adding a reducing agent to a solution containing an impurity derived fromAt. The invention also provides a solution containingAt(astatide ion) at a radiochemical purity of not less than 30%.

Astatine solution and method for producing same

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X isAt,At,I,I,I, orI. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)) or an ester group thereof, with a radionuclide selected fromAt,At,I,I,I andI, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

Production method for radiolabeled aryl compound

The invention relates to a method of producing the radiolabeled aryl compound (I) Ar&#x2014;X, or a salt thereof, wherein X isAt,At,I,I,I, orI. The method involves reacting the aryl boronic acid compound (II) Ar&#x2014;Y, or a salt thereof, wherein Y is a borono group (&#x2014;B(OH)) or an ester group thereof, with a radionuclide selected fromAt,At,I,I,I andI, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

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Suita, Japan

Jun Hatazawa