Olympus Optical Company, Ltd.

Olympus Corporation

Kabushiki Kaisha Toshiba

Olympus Medical Systems Corporation

Fuji Photo Film Company, Limited

Daiichi Sankyo Company, Limited

Nippon Zeon Company, Ltd.

Dai Nippon Printing Co., Ltd.

Nippondenso Co., Ltd.

Nippon Sheet Glass Company, Limited

Other

Canon Kabushiki Kaisha

Denso Corporation

Fujifilm Corporation

Fuji Electric Co., Ltd.

Jun Hasegawa

Katsuyoshi Sasagawa

Masahiko Sasaki

Shinji Yamashita

Masahide Kanno

Akinobu Uchikubo

Masao Uehara

Katsuyuki Saito

Tetsuo Nonami

Takehiro Nakagawa

Hideki Tanaka

Akira Taniguchi

Toshitada Saito

Hitoshi Saito

Toshio Nakamura

Hirokazu Nishimura

Takashi Miida

Fumiyuki Onoda

Toshio Fujisawa

Masanori Torii

Hiroshi Ishii

Hiroki Moriyama

Yasuo Hirata

Yoshinao Oaki

Ryohei Takiguchi

Kazutaka Tsuji

Takeshi Kawabata

Katsumi Hirakawa

Sumihiro Uchimura

Eiji Yamamoto

Kazunari Nakamura

Osamu Kobayashi

Hideo H Fujimura

Yoshinori Nakamura

Jun Hane

Michiyuki Kono

Toshiyuki Sato

Kenji Kimura

Hiroshi Yamada

Hiroki Hibino

Yuji Sakai

Masahiro Yamaguchi

Hiromasa Fujita

Shigeo Mori

Makoto Watanabe

Masatoshi Homan

Shinichiro Hattori

Seiichi Ito

Makoto Ueda

Hiroshi Iijima

Kazuhiro Kawajiri

Kimihiko Naito

Toshinori Agatsuma

Chieko Aizawa

Ryoko Inoue

Takayasu Miyagi

Tsugio Okazaki

Toshiaki Ohtsuka

Seiki Toriyama

Syunya Akimoto

Tokudai Ogawa

Atsushi Urano

Masanao Hara

Daisuke Okajima

Hirofumi Hamada

Shu Takahashi

Yasuhiro Yoshizawa

Keiichi Hiyama

Takako Kimura

Junichi Onishi

Tatsuya Inoue

Takeshi Takizawa

Masayoshi Sekiya

Noboru Yanagida

Takahiro Takasaki

Tatsuji Matsuoka

Yoshitaka Miyoshi

Yumi Matsui

Yoshimitsu Shimojo

Ryo Tojo

Hiroyuki Ushifusa

Shunya Akimoto

Hiroshi Tomita

Soichiro Koshika

Soichi Ikuma

Kazuma Kaneko

Tetsuo Shiraiwa

Yutaka Aoyama

Shoichi Amano

Ryokichi Doi

Tomohiko Oda

Hisanao Kojima

Kazunori Shigemori

Akihiko Yajima

Isao Taniguchi

Hiroshi Iwabuchi

Nobuyasu Ota

Hiromochi Muramatsu

Hirohito Komori

A display control system includes at least one processor that obtains shared information shared by a plurality of users, obtains individual setting information specified by a display-request user among the plurality of users, the display-request user being a user who requests display of the shared information, the individual setting information being related to an individual display setting of the display-request user, and displays the shared information on a display of the display-request user based on the individual setting information.

Display control system, display control method, and information storage medium

It is intended to provide an antitumor drug having an excellent therapeutic effect, which is excellent in terms of antitumor effect and safety. There is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-TROP2 antibody via a linker having a structure represented by the following formula: -L-L-L-NH&#x2014;(CH)n-L-(CH)n-C(&#x2550;O)&#x2014; wherein the anti-TROP2 antibody is connected to the terminal of L, and the antitumor compound is connected to the carbonyl group of the &#x2014;(CH)n-C(&#x2550;O)&#x2014; moiety with the nitrogen atom of the amino group at position 1 as a connecting position.

Anti-TROP2 antibody-drug conjugate

A medical instrument includes an insertion portion, first transmitting coils, second transmitting coils, a signal control unit, a position detection unit, a memory, and a position estimating unit. The signal control unit controls the first transmitting coils to transmit magnetic fields during a first predetermined period and controls the second transmitting coils to transmit magnetic fields during a second predetermined period. The position detection unit detects positions of the first transmitting coils during the first predetermined period and detects positions of the second transmitting coils during the second predetermined period. The memory stores the positions of the first transmitting coils. The position estimating unit estimates a shape of the insertion portion based on the positions of the second transmitting coils and the positions of the first transmitting coils stored in the memory.

Medical instrument

An endoscope system includes: an insertion portion to be inserted into a predetermined luminal organ in a subject; an image pickup section provided in a vicinity of a distal end of the insertion portion, the image pickup section picking up an image of a predetermined range; an image pickup information acquiring section acquiring position information and gaze information about the image pickup section; a model image generating section generating a planar model image of the predetermined luminal organ; an image pasting processing section generating a pasted image obtained by pasting a subject image of an inside of the predetermined luminal organ onto the planar model image based on the position information and gaze information about the image pickup section; and an image pasting/presentation processing section presenting an image pickup range of the image pickup section on the pasted image based on the position information about the image pickup section.

Endoscope system with image pasting on planar model

A medical apparatus includes: an information acquisition section configured to acquire position information and visual line information in an endoscope inserted into a predetermined organ; an image acquisition section configured to acquire an image obtained by observing inside of the predetermined organ from a predetermined viewpoint; an alignment section configured to convert the position information and the visual line information to a coordinate system of a model of the predetermined organ; a position calculation section configured to calculate position information of an inner wall of the predetermined organ opposing in a visual line direction from the predetermined viewpoint; an index generation section configured to generate an index defined based on a predetermined feature; and an image generation section configured to generate an image in which the index and position information of the inner wall are associated, for the image acquired by the image acquisition section.

Medical apparatus for associating index indicating priority corresponding to lesion occurrence frequency with position of inner wall opposing in visual line direction of endoscope the position being one at which image is acquired

The purpose of the present invention is to provide a substance having superior antibacterial activity against, and a pharmaceutical composition for treatment and/or prophylaxis of pseudomonal infections. A pharmaceutical composition is provided, containing an antibody which specifically binds to the LPS O11 antigen of, and which has superior antibacterial activity.

Anti-LPS O11 antibody

A tubular insertion system includes an insertion unit including a bendable portion, a bending operation mechanism that operates the bendable portion. The tubular insertion system further includes a bending operation amount detection/calculation device that calculates bending operation amount information, a bent shape detection/calculation device that calculates bent shape information, and a first operation support information acquisition unit that acquires first operation support information based on at least one of the bending operation amount information and the bent shape information.

Tubular insertion system

An image processing apparatus for scanning endoscope includes: a number-of-interpolations determination section that receives detection signals from a detector for sequentially sampling return light from a subject and determines a number of detection signals used in an interpolation process by an interpolation section based on distances between a coordinate position of a predetermined lattice point in pixel data of a raster scan system and sampling coordinate positions of the detection signals around the coordinate position of the predetermined lattice point; and the interpolation section that generates pixel data of the predetermined lattice point by using signals of the sampling coordinate positions, wherein a number of the signals is equal to the number of detection signals determined by the number-of-interpolations determination section near the sampling coordinate position corresponding to the coordinate position of the predetermined lattice point.

Image processing apparatus for scanning endoscope

A semiconductor circuit has circuit units in a plurality of stages which units are continuously connected, each of the circuit units in the plurality of stages including: a first register; a second register; a first outputter; and a second outputter. The first outputter is connected to the first register and the second register, and selects and outputs one of a first input signal inputted from the first register and a second input signal inputted from the second register. The second outputter outputs at least one of the second input signal and a third input signal to a second register in a next stage, the third input signal being outputted from a logic circuit unit that performs logic operation on the basis of an input signal containing at least one of a signals outputted from the first outputters.

Semiconductor circuit and semiconductor system

The present invention provides an antibody which binds to a fibroblast growth factor receptor.

Anti-FGFR2 antibodies and methods of use thereof for treating cancer

The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Anti-ROBO4 antibody

The endoscope system includes: an endoscope including an insertion portion to be inserted into a subject, and an image pickup portion that picks up an image of inside of the subject; an image pickup information acquisition portion that acquires positional information of the image pickup portion; an insertion form information acquisition portion that acquires insertion form information of the insertion portion inside the subject; and a control portion that, on a stereoscopic model image that simulates a predetermined organ inside the subject, superimposes an insertion form image that is based on insertion form information that is acquired by the insertion form information acquisition portion, and based on positional information of the image pickup portion that is acquired by the image pickup information acquisition portion, also pastes an image pickup image that is picked up by the image pickup portion, and presents the resulting stereoscopic model image.

Endoscope system for presenting three-dimensional model image with insertion form image and image pickup image

Problem to be Solved The present invention relates to an antibody having an anti-angiogenesis activity. More specifically, the present invention relates to an antibody against ROBO4 and a pharmaceutical composition containing the antibody. An object of the present invention is to provide an anti-ROBO4 antibody having an anti-angiogenesis effect, a pharmaceutical composition or the like comprising the antibody, a method for suppressing angiogenesis using the antibody, etc. Another object of the present invention is to provide a method for producing the antibody. The antibody of the present invention activates the downstream signal of ROBO4 and has a suppressive activity against cell migration induced by VEGF or bFGF. The antibody of the present invention also exhibits an anti-angiogenesis effect in in-vivo models.

Growing community of inventors

Hino, Japan

Jun Hasegawa