National University of Singapore

Nkarta, Inc.

Jun Hao Leong

Dario Campana

Alexandra Leida Liana Lazetic

James Barnaby Trager

Chao Guo

Luxuan Guo Buren

See Voon Seow

Noriko Shimasaki

Shyam Sashikant Masrani

Several embodiments disclosed herein relate to the compositions comprising engineered Natural Killer (NK) cells that express a chimeric receptor, the chimeric receptor imparting to the NK cells an enhanced ability to target specific cells, such as cancerous cells or those affected by an infectious disease. Several embodiments relate to NK cells that target cells expressing natural ligands of NKG2D, where the NK cells comprise transmembrane and/or signaling domains that lead to cytotoxic and/or cytolytic effects when the NK cells bind a target cell. Uses of NK cell compositions to treat diseases are also provided for in several embodiments.

Immune cells comprising truncated NKG2D chimeric receptors

Truncated NKG2D chimeric receptors and uses thereof in natural killer cell immunotherapy

Growing community of inventors

Singapore, Singapore

Jun Hao Leong