University of Georgia Research Foundation, Inc.

Jun Guo

Geert-Jan Boons

Xinghai Ning

Margaretha Wolfert

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds

Compounds and methods for use in selectively inhibiting a lytic enzyme based on feedback inhibition are described. The conjugated compound serves as a substrate for a lytic enzyme. Cleavage of the conjugated compound by the lytic enzyme releases an inhibitor of the enzyme.

Growing community of inventors

Athens, GA, United States of America

Jun Guo