Ajou University Industry-Academic Cooperation Foundation

Jun Gi Rho

Wook Hwan Kim

Jong Hyun Kim

Jae Hyung Park

EunHa Kim

Juhwan Yoon

Hwa Seung Han

June Sung

The present invention relates to a novel near-infrared fluorescent probe having specificity for mitochondria due to a hydrophobic group attached to a silicon-rhodamine core, and the use thereof for mitochondrial detection and cancer diagnosis. The fluorescent probe of the present invention has improved mitochondrial targeting efficiency compared to conventional probes due to a hydrophobic group attached to a silicon-rhodamine core, can detect mitochondria in living tissue with high sensitivity and specificity in a near-infrared (NIR) region (700 to 1,700 nm), and can acquire three-dimensional high-resolution biological images without harming the human body. Due to these advantages, the fluorescent probe can be used not only for mitochondrial detection in cells in the laboratory, but also as a contrast agent or a drug delivery carrier in cancer diagnosis and surgery.

Silicon-rhodamine fluorescent probe containing hydrophobic group and use thereof

Disclosed is use of a composition for preventing or treating an inflammatory disease and a metabolic disease. The composition includes hyaluronic acid nanoparticles formed in such a way that 5&#x3b2;-cholanic acid or polycaprolactone binds to a hydrophobic moiety of hyaluronic acid through self-assembly in an aqueous solution state.

Pharmaceutical composition containing hyaluronic acid nanoparticles for preventing or treating inflammatory disease and metabolic disease

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Ansan-si, South Korea

Jun Gi Rho