Leland Stanford Junior University

The University of Arizona

The Francis Crick Institute Limited

Jun Ding

Nicholas A Melosh

Leilei Peng

Mina-Elraheb Saad Hanna

Andreas Schaefer

Matt R Angle

Dongli Xu

A microscopic technique for generating high-clarity, large volume 3D images of fluorescent tissue structure at subcellular resolution and capture transient activities. The technique includes capturing two orthogonal 2D projection of the sample volume by performing a projection scan with an excitation laser sweeping through the volume at up to 100 vps, tracking the scan depth using an electrically tuned lens to keep the emission image in focus and generate an xy plane volume projection image at the camera; and placing a PMT behind the excitation lens to collect emission passed through the excitation lens, wherein signals from the PMT form a focus scan projection at the yz plane; and then merging the xy and yz projections.

Fast volumetric imaging system and process for fluorescent tissue structures and activities

A probe suitable for deep-brain recording and stimulation is provided. The probe comprises a wire bundle that includes a plurality of wires, an integrated circuit having a plurality of electrodes, and an interposer that joins the wire bundle and the integrated circuit such that each of the plurality of electrodes is electrically connected with a different wire of the plurality of wires.

Deep-brain probe and method for recording and stimulating brain activity

Growing community of inventors

Palo Alto, CA, United States of America

Jun Ding