Zenyaku Kogyo Kabushiki Kaisha

Juntendo Educational Foundation

Zenyaku Kogyo Co., Ltd.

Jumpei Enami

Hirokazu Suzuki

Keiichi Hiramatsu

Takahiro Ohashi

Tetsuo Sasaki

Hitoshi Miyashita

Satoko Tatebe

Hiroyoshi Ohsawa

Yasukatsu Tsukada

Provided is an antibody that has a high binding activity to membrane-bound IgM on the surface of B cells and exhibits a growth inhibition effect on the B cells, even in the presence of soluble IgM in blood. A bispecific antibody, which binds to IgM and a B cell surface antigen.

Anti-IgM/B cell surface antigen bispecific antibody

[Problem] To provide: an antibody comprising at least two kinds of Fab, and in particular having restricted light chain-heavy chain combinations; a corresponding antibody composition; and production methods for same. [Solution] The present invention provides production methods for (1) an antibody or (2) an antibody composition, the methods using non-natural disulfide bonds.

Antibody and antibody composition production method

[Problem] The present invention addresses the problem of providing an anti-antibody having preventive or therapeutic effects on staphylococcal infections. [Solution] Provided is an anti-antibody having preventive or therapeutic effects on staphylococcal infections and a method for manufacturing said antibody, as well as a composition, a product, and a drug containing said antibody. The antibody is obtained by using deacetylatedfor immunization.

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Growing community of inventors

Nerima-ku, Japan

Jumpei Enami