The State University of New York

Path, Inc.

Jumin Geng

Jonathan Lovell

Shuai Shao

Charles Richter King

Shwu-Maan Lee

Wei-Chiao Huang

Wentao Song

Kevin Carter

Yumiao Zhang

Chulhong Kim

Mansik Jeon

Dandan Luo

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules comprising epitopes from microorganisms with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.

Nanostructures comprising cobalt porphyrin-phospholipid conjugates and polyhistidine-tags

Provided are serum-stable nanoparticles comprising porphyrin-phospholipid conjugates. Also provided are compositions comprising the nano-particles. The nanoparticles can comprise cargo such as therapeutic agents and/or diagnostic agents (e.g., imaging agents) and be used in drug delivery methods based on NIR stimulated cargo release.

Serum-stable compositions and methods for light-triggered release of materials

The present disclosure provides nanostructures (e.g., monolayer or bilayer nanostructures) comprising porphyrins with cobalt chelated thereto such that the cobalt metal resides within monolayer or bilayer in the porphyrin macrocycle. The nanostructures can have presentation molecules with a histidine tag attached thereto, such that at least a part of the his-tag is within the monolayer or bilayer and coordinated to the cobalt metal core and the presentation molecules are exposed to the outside of the nanostructures. The nanostructures can further comprise a cargo. The nanostructures can be used to deliver the cargo to an individual.

Provided are compositions and methods relating to hydrophobic agent loaded-micelle. The micelles comprise surfactant (such as poloxamer) and have hydrophobic agents incorporated therein. The compositions substantially lack surfactant that is not associated with the micelles. The compositions are able to achieve high hydrophobic agent: surfactant molar ratio. The compositions can be used for drug delivery and imaging applications.

Surfactant-stripped micelle compositions with high cargo to surfactant ratio

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Williamsville, NY, United States of America

Jumin Geng