Bracco Diagnostics Inc.

Bracco International Bv

Dibra S.p.a.

Bracco Research, USA

Julius P Zodda

Rolf E Swenson

Janet L Gelbach

Stephen E Hidem

Aaron M Fontaine

Patrick M McDonald

Kathryn M Hunter

Irene K Ropiak

Charles R Quirico

Ernst Schramm

Jo Anna Monteferrante

John J Niedospial, Jr

Ernest Balestracci

James A Melchore, Jr

Michael N Eakins

Michelle L Robinson

Margaret Newborn

Christoph De Haen

Fred E Snyder

Rama K Narra

Anne Marie Smith

Rebecca V Fisher

Lawrence Callan

Angelo Gallotti

Irene Kucharewicz Ropiak

Irene Ropiak

Thomas Katona

Ernest Schramm

Bruce Kuczynski

Edmund C Metcalfe

Gregory W White

Kimberly J McDaniel

James A Melchore

Patrick M Mcdonald

Kimberly J Mcdaniel

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Integrated strontium-rubidium radioisotope infusion systems

Integrated Strontium-Rubidium radioisotope infusion systems

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer includes pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

Infusion systems including computer-facilitated maintenance and/or operation and methods of use

A radioisotope generator system can include a column assembly having a column, an inlet arm, an outlet arm. The column can contain packing material that binds a radioisotope. In addition, the column may define a notch between an open area and a stopper receptacle area in which an opening of the outlet arm is positioned. In some examples, the system includes a Luer lock connection between the outlet arm and a connector tubing. The Luer lock connection can include a male Luer cap and a female Luer cap each comprising tabs configured to line up with or overlap each other so as to indicate when the caps are sufficiently tightened together so as to form a non-leaking lock.

Containers for pharmaceuticals, particularly for use in radioisotope generators

Infusion system with radioisotope detector

Radioisotope generator system including activity measurement and dose calibration

The invention is directed to improved containers for pharmaceuticals and any tubing and tubing connectors associated therewith, particularly containers for pharmaceuticals which are irradiated, heated or otherwise subjected to increased pressure. In a preferred embodiment, the invention is directed to an improved container for use in a radioisotope generator, such as a rubidium-82 generator.

The invention features sincalide formulations that include an effective amount of sincalide, a bulking agent/tonicity adjuster, a stabilizer, a surfactant, a chelator, and a buffer. The invention also features kits and methods for preparing improved sincalide formulations, as well as methods for treating, preventing, and diagnosing gall bladder-related disorders using sincalide formulations.

Sincalide formulations

Manufacturing process to control particle size

A kit containing a solution of boronic acid adducts of technetium-99 m dioxime complexes; and hydroxypropyl gamma cyclodextrin to maintain the solution free of particulate matter originating from the formulation.

Kit for the preparation of technetium TC 99m teboroxime myocardial

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Mercerville, NJ, United States of America

Julius P Zodda