University of Arkansas

Embrex, Inc.

Other

Zoetis Services LLC

James E. Hutchins

Julius K. Tyczkowski

Julius K Tyczkowski

Craig E Whitfill

Tommy L Fredericksen

J Paul Thaxton, Jr

John A Thoma

James E Hutchins

Patricia V Phelps

John Allen Thomas

Alan P Avakian

James P Thaxton

Vivian W Doelling

Toni O O'Connell

Ann B Gore

Cherilyn L Heggen-Peay

The present invention provides improved methods and compositions for producing oocysts. The oocysts produced according to the invention find use in the manufacture of vaccines. In preferred embodiments, the present invention provides methods and compositions for the production ofoocysts. Vaccines containingoocysts, sporocysts and/or sporozoites produced according to the present invention may be used to immunize birds against coccidiosis either in ovo or post hatch.

Methods for producing oocysts

A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine conjugate consisting essentially of a live virus and a neutralizing factor bound to the live virus. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus. Preferred subjects are birds, a preferred virus is Infectious Bursal Disease Virus, and a preferred route of administration to birds is by in ovo administration.

Method of treatment

Method of treating viral diseases in animals

A method of producing active immunity against a viral disease in an animal subject comprises administering to the subject a vaccine complex consisting essentially of a live virus and a neutralizing factor bound to the live virus. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus. Preferred subjects are birds, a preferred virus is Infectious Bursal Disease Virus, and a preferred route of administration to birds is by in ovo administration.

Method of treating Infectious Bursal Disease Virus infections

A method of producing active immunity against infectious bursal disease virus in an avian subject comprises administering to the subject a vaccine complex consisting essentially of a live virus and a neutralizing factor bound to the live virus. The neutralizing factor is selected from the group consisting of antibodies and antibody fragments. The live virus is one capable of producing disease in the subject, and the antibody or antibody fragment is one capable of neutralizing the live virus. A preferred route of administration to birds is by in ovo administration.

Method of treating infectious bursal disease virus infections

A method of introducing a substance into a bird egg through the shell thereof comprises the steps of applying a seal to the exterior of the shell, inserting an injection device through the seal and into the egg, injecting the substance through the injection device and into the interior of the egg, and withdrawing the injection device from the egg through the seal. The method is particularly preferred for injecting substances into the albumin during the first quarter of injection through the bottom of the egg when the small end of the egg is oriented downward to prevent the introduction of air bubbles through the opening formed in the shell by the injection device.

Method of introducing material into eggs during early embryonic

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Cary, NC, United States of America

Julius K Tyczkowski