University of California

Julius Guccione

Kevin Edward Healy

Samuel Thomas Wall

Mark B Ratcliffe

The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineering applications, as a supporting matrix in the stabilization of an injured or defective myocardial wall in a patient comprising injecting a polymer network at a pre-selected site in the myocardial wall of the patient.

Methods and compositions for stabilizing the myocardium

The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineer applications, as a supporting matrix in the stabilization of the myocardium. For example, the present invention provides methods of stabilizing an injured or defective myocardial wall in a patient including forming a prosthetic in situ by injecting, at a pre-selected site in the myocardial wall of the patient, a polymer network including: a cross-linked polymer, the cross-linked polymer being a hydrogel; and a linear polymer, the polymer chains of which are entangled within the cross-linked polymer, wherein the linear polymer is not covalently bonded to the cross-linked polymer.

The present invention provides materials and methods that can serve as a prosthetic and/or, for tissue engineer applications, as a supporting matrix in the stabilization of the myocardium.

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El Cerrito, CA, United States of America

Julius Guccione