University of Pittsburgh

Julius Chung

A method for chemical exchange saturation transfer (CEST) MRI using an average saturation efficiency filter (ASEF)/adjustment of rotation and saturation effects (AROSE) includes: applying a first RF pulse train including a high duty cycle, the first RF pulse causing magnetization of exchangeable protons based on saturation and/or rotation effects, transferred to a water pool of a target structure; discontinuing application of the first RF pulse train; acquiring a first water MR signal; applying a second RF pulse train including a low duty cycle, the second RF pulse train causing magnetization of the target molecules based at least in part on saturation transfer and either minimizing rotation transfer with bipolar pulses or adjusting rotation transfer with selected flip angles; discontinuing application of the second RF pulse train; acquiring a second water MR signal; and generating ASEF/AROSE signal representing a difference between the first and second water MR signals.

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PITTSBURGH, PA, United States of America

Julius Chung