Xsynchro, Inc.

Synchromax, Inc.

Julio César Spinelli

Luis Dante Barja

Maria Paula Bonomini

Marco Peresini

One embodiment provides a system for cardiac stimulation optimization utilizing cardiac asynchrony and pulse pressure data. The system includes: an analysis circuitry to receive cardiac signals collected at two locations of a patient's heart during an application to the heart of stimulation in accordance with multiple (VV) delay intervals, calculate an asynchrony index for the VV delay intervals, and determine one of the VV intervals as optimal based on the asynchrony index for that VV interval; an implantable stimulation device to cycle through the VV intervals while applying the stimulation, and further configured to cycle through atrioventricular (AV) delay intervals while applying additional stimulation in accordance with the optimal VV delay interval; and an arterial pulse pressure sensor to measure arterial pulse pressure during the application of the additional stimulation, wherein the analysis circuitry determines one of the AV delay intervals as optimal based on the arterial pulse pressure measured.

System for cardiac stimulation optimization utilizing cardiac asynchrony and pulse pressure data

One embodiment provides a system for determination and utilization of cardiac electrical asynchrony data. The system includes an analysis circuitry including a processor and a memory, the analysis circuitry configured to: obtain a plurality of sets of cardiac signals collected in at least two locations of a heart of a patient, the signals comprising at least one of surface electrocardiography signals and pseudo-surface ECG signals; detect one or more QRS complexes for each of the sets based on the cardiac signals for that set; obtain one or more cross-correlation signals, each of the cross-correlation signals being between at least two of the signal sets and being obtained using the detected QRS complexes from the signal sets; and calculate one or more asynchrony indices using one or more of the cross-correlation signals, each of the asynchrony indices being indicative of a level of asynchrony between the at least two locations.

System for determination and utilization of cardiac electrical asynchrony data

Device, systems, methods and kits can be useful for auricular stimulation. One such device relates to auricular stimulation. The device includes an earpiece having an electrode arrangement configured and arranged to deliver a series of electrical stimulation signals to an auricular location. A pulse-generator circuit is configured and arranged to generate the series of electrical stimulation signals having a stimulation profile, and to deliver the electrical stimulation signals to the electrode arrangement. A sensor is configured and arranged to generate a feedback signal that is responsive to the electrical stimulation signals. A feedback circuit is configured and arranged to modify the stimulation profile in response to the feedback signal.

Auricular stimulation for inflammatory parasympathetic diseases

Various aspects of the present disclosure are directed toward an asynchrony index that is related to data of a subject's heart. The asynchrony index includes intra-ventricular or inter-ventricular electrical asynchrony data. The intra-ventricular or inter-ventricular electrical asynchrony data can be specific to a certain subject, and indicative of a different conditions specific to that subject.

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Bradenton, FL, United States of America

Julio César Spinelli