Esteve Quimica S.a.

Julio Campon Pardo

Ramón Berenguer Maimó

Jorge Medrano Rupérez

Laura Coppi

Laia Elías Rius

Yolanda Gasanz Guillen

Josep M Ribalta Baro

Gloria Oranias Olsina

Process for removal of the amino protective group of a N-acylated {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-cyclopent-2-enyl}methanol of formula (II) where R&#x2550;H or a (C-C)-alkyl, using an inorganic base in a mixture of water and alcohol, to yield abacavir or its salts. The process proceeds very fast and the product can be obtained in high yield and purity. 

Process for the preparation of abacavir

Process for the preparation of abacavir, or its salts or its solvates comprising the step of reacting a compound (IV) where Ris a (C-C)-alkyl radical with anhydrous hydrochloric acid/(C-C)-alcohol, and then with tri(C-C)-alkyl orthoformate, in the absence of water. The preparation process may include further steps of reacting the compound obtained with cyclopropylamine and subsequently hydrolysis to yield abacavir. 

Process for preparing purified citalopram or one of its salts that comprises the purification of citalopram by selective extractions of citalopram or of its impurities with organic solvents and water under specific conditions of pH and temperature. The crude citalopram can be prepared by a process that comprises reacting 1-&lsqb;3-(dimethylamine)propyl&rsqb;-1-(4-fluorophenyl)-1,3-dihydro-5-bromoisobenzofuran with copper cyanide.

Process for preparing citalopram

The present invention relates to a procedure for the oxidation of a thioether group to a sulfoxide group, with aqueous sodium percarbonate in the presence of a molybdenum salt as a catalyst. The procedure is of application to oxidize the thioether group of a compound (I), where R is a C -C alkyl, a halogenated C -C alkyl, or &mdash;(CH ) &mdash;OR , where n is an integer between 1 and 6 and R is H or a C -C alkyl; R , R , R , R , R and R , independently form each other represent H, a C -C alkyl, or C -C alkoxy; and R is H, a C -C alkyl, a C -C alkoxy or a C -C fluorinated alkoxy, in order to obtain the sulfinyl derivative (II).

Method for oxidizing a thioether group into a sulfoxide group

Industrial process for obtaining an aryloxypropanolamine of chemical name 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol, characterized in that it comprises the following operating phases. By reacting 4-(2-methoxyethyl)phenol with epichlorohydrin in an alkaline aqueous medium at temperatures of between 0.degree. and 25.degree. C. a crude reaction product composed to the extent of 75-80% of 3-[4-(2-methoxyethyl)phenoxy]-1,2-epoxypropane and to the extent of 15-20% of 1-[4-(2-methoxyethyl)phenoxy]-3-chloro-2-propanol is obtained, after the appropriate extractions and washings, both compounds being suitable for reacting with isopropylamine in an aqueous medium and at temperatures ranging between 0.degree. and 30.degree. C. to obtain the desired aryloxypropanolamine of formula I.

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Barcelona, Spain

Julio Campon Pardo