Ludwig Institute for Cancer Research Limited

Julio C Castro-Palomino

Lloyd J Old

Gerd J Ritter

Richard R Schmidt

Andreas Doll

The invention describes an improved method for making monosialoganglioside GM3 and its intermediates. Following reaction of a neuraminic acid donor and a lactose acceptor in the presence of an acid catalyst, the .alpha. and .beta. isomers of GM3 are formed. The .alpha. isomer is converted to a lactone, via action of a ring forming basic catalyst, which is then separable from the .beta. isomer. The lactone is then treated with a basic catalyst in the presence of an alcohol, to form GM3 or a GM3 intermediate.

Methods of synthesizing GM3

This invention relates to methods of producing synthetic GM2s. The methods are simple and efficient, and result in high yields of GM2s.

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Constance, Germany

Julio C Castro-Palomino