Louisiana State University and Agricultural & Mechanical College

The Foundation for the Lsu Health Sciences Center

Other

Zambon Group S.p.a.

Alter, S.a.

South Rampart Pharma, LLC

Universidad De Alcalà

University of Alcala De Henares

Julio Alvarez-Builla

Nicolas G Bazan

Carlos Sunkel

Dennis J Paul

Gabriele Pietro Norcini

Francesco Santangelo

Mauro Napoletano

Gabriele Morazzoni

Giancarlo Grancini

Daniela Botta

Hernan Bazan

Juan J Vaquero

Fernando Dorrego

Basilio Pando

Jorge G Siro Herrero

Carlos Galera

Alberto E Musto

Maria L Vazquez

Miguel Fay De Casa Juana

Jos&eacute; Luis Garcia Navaio

Anthony Vaccarino

Carolina Burgos

Provided are compositions that include a platelet-activating factor antagonist, pharmaceutical compositions including the platelet-activating factor antagonist, methods of treating a modulating the proliferation of a glioma or a pathological condition resulting from patient having a glioma.

Compositions and methods for the treatment of seizure caused by brain tumor

This invention is directed to compositions, methods and kits that can be used for the treatment or amelioration of pain.

Compositions and methods for ameliorating pain

The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with caffeine and an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency and are free from antipyretic activity, do not suppress blood coagulation, and have little hepatotoxic effect.

Synergistic combinations including N-acylated 4-Hydroxyphenylamine derivatives and caffeine

The present invention relates to pharmaceutical combinations of opioid and non-opioid analgesics in an intimate admixture with an analgesic from a series of N-acylated 4-hydroxyphenylamine derivatives, linked via an alkylene bridge to the nitrogen atom of a 1,2-benzisothiazol-3(2H)-one 1,1-dioxide group and methods for their use to alleviate pain in mammals. The analgesic combinations exhibit enhanced analgesic potency, do not suppress blood coagulation, and have little hepatotoxic effect.

Synergistic combinations including N-acylated 4-hydroxyphenylamine derivatives

New analgesic compounds, which are prepared by the hydrolysis of N-acylated 4-hydroxyphenylamine derivatives, their synthesis and pharmaceutical compositions containing them are disclosed. These compounds surprisingly possess high analgesic activity with little hepatotoxic effect, making them more useful than conventional non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of chronic pain.

Analgesic compounds, their synthesis and pharmaceutical compositions containing them

Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C )alkyl optionally substituted; R is (C )alkyl or polyfluoro(C )-alkyl; R is (C )cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N&rarr;O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF&agr; inhibitors.

Phthalazine derivatives as phosphodiesterase 4 inhibitors

Novel quaternary ammonium salts of general formula (I) ##STR1## wherein: R is a saturated or unsaturated, linear or branched alkyl radical of C.sub.1 to C.sub.8.

Quaternary ammonium salts used as phase transfer catalyst

Growing community of inventors

Madrid, Spain

Julio Alvarez-Builla