University of Colorado

Harvard College

Juliet T Gopinath

Victor M Bright

Emily A Gibson

Mo Zohrabi

Omkar D Supekar

Robert H Cormack

Diego Restrepo

Richard L Weir

Wei Yang Lim

Andrew M Jones

Baris Ozbay

Robert D Niederriter

Joseph J Brown

Alan R Greenberg

Gregory Brian Rieker

Michael P Brenner

Lior Cohen

Stephanie A Meyer

Mark E Siemens

Brendan M Heffernan

Connor McCullough

Gregory Krueper

Alexander Anderson

Elizabeth F Strong

A system for sensing phase changes in a medium includes a bidirectional interferometer having a reference arm and a sensing arm, two inputs at each of the two ends of the interferometer, and a circulator disposed between each input and the interferometer. Sources provide squeezed state pulses at an input at each end of the interferometer. Spaced-apart partial reflectors are disposed along the arms. There are detectors associated with each input. The circulators pass the squeezed state pulses into the interferometer and route reflections of the pulses to the detectors. Classical pulses may provided at the other input at each end of the interferometer.

Quantum sensing and computing using cascaded phases

A structured-light-velocimetry method includes extracting one or more bursts from a time-varying signal generated by detecting scattered light from a tracer particle passing through a structured optical beam; fitting each of the one or more bursts to a multi-variable model to extract a plurality of fitted parameters; and executing a machine-learning model with the plurality of fitted parameters to predict an angular velocity of the tracer particle.

Structured-light velocimeter and velocimetry method

The present disclosure relates optical imaging devices and methods useful in biological and medical imaging applications. In one embodiment, an optical imaging device includes a flexible lightguide having a first end and a second end, the output of the source of pulsed infrared radiation being optically coupled to the first end of the flexible lightguide; a lens assembly attached to and optically coupled to the second end of the flexible lightguide, the lens assembly comprising a variable-focus lens element, the a variable-focus lens element having a tunable focal length; and a photodetector coupled to the flexible lightguide to detect radiation propagating from the second end toward the first end of the flexible lightguide. The optical imaging devices and methods can be used in both confocal and multi-photon techniques.

Optical imaging devices and variable-focus lens elements, and methods for using them

Sub-diffraction limited fluorescent images using a fiber-based stimulated emission depletion (STED) microscope are reported. Both excitation and depletion beams are transported through polarization-maintaining fiber and a lateral resolution of 100 nm has been achieved.

Methods and systems for stimulated emission depletion microscopy

The present disclosure relates generally to methods and systems useful in imaging applications, especially biological imaging applications, and applications in the metrology, atmospheric, scientific and medical fields. In one aspect, the disclosure provides a method of imaging an object, including illuminating the object with incident radiation through one or more adaptive optical elements; receiving transmitted radiation from the object at a photodetector to provide a base image; and performing the following steps one or more times: adjusting the one or more adaptive optical elements, the adjustment including modifying an optical transfer function of the one or more adaptive optical elements, and receiving transmitted radiation from the object at the photodetector to provide an adjusted image; wherein the adjustment and receiving steps are performed until the adjusted image has substantially reduced aberrations compared to the base image.

Methods and systems for imaging with aberration correction

A tunable optical electrowetting element having a liquid-liquid interface shape controlled by an applied voltage. Circuitry for applying a voltage to the electrowetting element is configured to apply a shaped voltage signal comprising a first fast-rising signal combined with a second fast-rising signal. The second signal is selected to damp oscillations in the liquid-liquid interface caused by the first signal.

Enhanced response time of tunable optical electrowetting elements with shaped input voltage functions

Electrowetting-actuated optical shutters based on total internal reflection or beam steering. An electrowetting cell contains a conducting liquid and a non-conducting liquid configured to form a liquid-liquid interface extending to the inner walls of the cell. A beam of light is directed to the liquid-liquid interface at an angle near the total internal reflection angle of the interface. Voltage changes the shape of the liquid-liquid interface, without separating it from the inner walls of the cell. Thus, when depending on the voltage applied, the beam is either transmitted in part or substantially totally internal reflected.

Optical shutters having offset liquid lenses

A system for high resolution multiphoton excitation microscopy is described herein. In one embodiment, the system may include an electrowetting on dielectric (EWOD) prism optically coupled to an excitation source, the EWOD prism adapted or configured to: receive a light beam from the excitation source, and project the received light beam onto a sample plane based on a tunable transmission angle of the EWOD prism, and a fluorescence imaging microscope adapted or configured to: receive a fluorescence signal from the sample plane based on the projected light beam, and relay the fluorescence signal from the sample plane to a set of detectors.

Electrowetting prism for scanning in high resolution fluorescence microscopy

Wide-angle beam steering using two or more variable lenses to form a small-angle beam steering element, along with a numerical aperture converter and a wide-angle lens. The small-angle beam steering element might comprise either one- or two-dimensional beam steering with tunable liquid lenses.

Wide-angle beam steering

A compact diode laser achieves high-power, short duration output pulses by separating the lasing action from the pulse-generating mechanism. A diode seed source is configured for gain-switching via a variable RF source. A time lens element includes an intensity modulation device, a phase modulation device, and a pulse compressor. The intensity modulation device carves shorter pulses from the long gain-switched seed pulses, the phase modulation device adds chirp, and the pulse compressor compensates for the chirp while producing high-power short-duration output pulses.

Compact diode laser source

Methods and devices for real-time detection of fouling chemistry are described herein. In one aspect, a method of detecting and characterizing fouling of a membrane used for separation in a fluid-based system can include illuminating the membrane with one or more light sources, collecting Raman spectroscopy data from the membrane, and based on the Raman data, determining at least one selected from the group consisting of: presence or absence of membrane fouling, severity of membrane fouling, and composition of the membrane fouling, where the Raman spectroscopy is selected from the group consisting of Coherent Anti-Stokes Raman Scattering (CARS), Stimulated Raman Scattering (SRS), and spontaneous Raman Scattering.

Growing community of inventors

Boulder, CO, United States of America

Juliet T Gopinath