Idorsia Pharmaceuticals Ltd

Actelion Pharmaceuticals Ltd

Julien Pothier

Heinz Fretz

Sylvia Richard-Bildstein

Philippe Guerry

Francois Lehembre

Hamed Aissaoui

Christoph Boss

Daniel Bur

Olivier Corminboeuf

Sylvaine Cren

Davide Pozzi

Thierry Kimmerlin

Isabelle Lyothier

Hervé Siendt

Laetitia Pouzol

Lorenza Wyder Peters

Shuguang Yuan

Philippe Risch

Kurt Hilpert

Thierry Sifferlen

Markus Gude

Corinna Grisostomi

Romain Siegrist

Xavier Leroy

Markus Riederer

Matthias Steger

Anja Valdenaire

Oliver Corminboeuf

Carina Lotz-Jenne

Naomi Tidten-Luksch

Herve Siendt

The present invention relates to derivatives of formula (I) wherein (R), R, R, R, R, R, Rand Arare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

N-substituted indole derivatives as PGE2 receptor modulators

The present invention relates to piperidine derivatives of formula (I) wherein Ar, Ar, R, R, R, and Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

Piperidine CXCR7 receptor modulators

The present invention relates to compounds of Formula (I) inhibiting indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) enzymes. Further, their synthesis and their use as medicaments in inter alia cancer is disclosed. 

Inhibitors of indoleamine 2,3-dioxygenase and/or tryptophan 2,3-dioxygenase

The present invention relates to piperidine derivatives of formula (I) wherein Ar, Ar, R, R, Rand Rare as described in the description, their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

Piperdine CXCR7 receptor modulators

The present invention relates to derivatives of formula (I) wherein (R), ring (A), Y, Y, X, R, L, L, and Arare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

CXCR7 receptor modulators

The present invention relates to derivatives of formula (I) wherein (R), R, R, R, R, R, L, L, X, Y and Arare as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.

The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein X, Y, Z, n, R, R, R, R, R, R, Rand Rare as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin Dreceptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

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The invention relates to aminopyrazole derivatives of formula (I), wherein A, E, Rand Rare as defined in the description, their preparation and their use as pharmaceutically active compounds.

Aminopyrazole derivatives

The invention relates to 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives and their use as potent 'chemoattractant receptor-homologous molecule expressed on Th2 cells' antagonists in the treatment of prostaglandin mediated diseases, to pharmaceutical compositions containing these derivatives and to processes for their preparation.

2-sulfanyl-benzoimidazol-1-yi-acetic acid derivatives as CRTH2 antagonists

The present invention relates to (3-amino-1,2,3,4-tetrahydro-9H-carbazol-9-yl)-acetic acid derivatives of Formula (I) wherein R, R, R, R, Rand Rare as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin Dreceptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation. 

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Allschwil, Switzerland

Julien Pothier