Recherche Et Industrie Therapeutiques (r.i.t.)

Smithkline Beecham Biologicals S.a.

Julien Peetermans

Pierre Hauser

Jean-Marie Prevost

Emil Vascoboinic

Michele Lobmann

The invention relates to a vaccine formulation for the prevention of Haemophilus Influenzae Type B (Hib) infections and where the antigen is adsorbed onto aluminum phosphate. The invention also relates to a multivalent vaccines, that is a vaccine for the amelioration or treatment of more than one disease states. The present invention also relates to the production and use of such vaccines in medicine.

Vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminum phosphate

Attenuated stable influenza type B virus strains are obtained by recombining a vaccinal and previously attenuated influenza type B virus strain with an influenza type B virus isolate having the desired serotype and isolating a recombinant having at least one marker property of the attenuated parent strain which is not shared by the other parent strain and the antigenic composition of the other parent strain. The obtained strains are useful for the production of nasal influenza vaccines.

Live influenza type B virus vaccines and preparation thereof

Stable H.sub.3 N.sub.2 influenza virus strains completely resistant to serum inhibitors are obtained by passaging at least one time in the allantoic cavity of embryonated eggs in the presence of serum a recombinant strain previously obtained from an H.sub.3 N.sub.2 influenza strain and the A/PR.sub.8 influenza virus strain and isolating the so-obtained serum inhibitors resistant strains. The obtained strains are useful for vaccine production.

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Rixensart, Belgium

Julien Peetermans