Vertex Pharmaceuticals, Inc.

Julien Martel

Yeeman K Ramtohul

Bingcan Liu

Frederic Vallee

Michel Gallant

Sanjoy Kumar Das

Carl Poisson

Thumkunta Jagadeeswar Reddy

Evelyne Dietrich

Louis Vaillancourt

Caroline Cadilhac

Stephanie Lessard

Luc J Farmer

Claudio F Sturino

Constantin G Yannopoulos

Monica Bubenik

Jean-Eric Lacoste

Janek Szychowski

Miguel St-Onge

Camil Elie Sayegh

Jean-Francois Lévesque

Pierre-Andre Fournier

Yeeman Ramtohul

The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I:  The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.

Mannose derivatives for treating bacterial infections

2,7-dibromospiro[fluorene-9,4'-piperidine] compounds

The present invention relates to compounds useful as inhibitors of the PAR-2 signaling pathway. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of GPCRs in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such GPCRs; and the comparative evaluation of new inhibitors of the PAR-2 signaling pathway. The compounds of this invention have formula I: wherein the variables are as defined herein.

Imidazopyridazines useful as inhibitors of the PAR-2 signaling pathway

The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I:  The invention also provides processes for making the compounds described herein. Furthermore, the present invention provides a composition comprising the compounds described herein, and a pharmaceutically acceptable carrier, adjuvant, or vehicle. The present invention also provides methods of treating or preventing bacteria infection in a subject, comprising administering to the subject an effective amount of the compound or the composition described herein.

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Montreal, Canada

Julien Martel