Centre National De La Recherche Scientifique

Université De Lille 1 - Sciences Et Technologies

Institut Pasteur De Lille

Université De Lille 2 Droit Et Santé

Innobiochips

Julien Dheur

Oleg Melnyk

Nathalie Ollivier

Reda Mhidia

Jean-Philippe Georges Bernard Ebran

Nabil Dendane

Vianney Souplet

Christophe Olivier

Method for preparing a peptide assembly of n fragments and n&#x2212;1 amino acids bearing a thiol function, represented by the formula:A-C-A-C-A- . . . -C-A- . . . -C-A&#x2003;&#x2003;(I)in which A, A, A, . . . A. . . , Aare peptide fragments, C, C, C. . . C. . . Care amino acid residues bearing a thiol function, n is comprised between 3 and 50, and i is 2 to n, in which a peptide-thioester is prepared of formula: A-SR (II) in which Ais a peptide fragment and SR is an alkyl thioester residue, R being alkyl optionally substituted, starting from a bis(2-sulphanylethyl)amino peptide.

Method for preparing peptides by assembling multiple peptide fragments

The invention relates to a device for detecting analytes, including a plastic substrate at least partially covered by bonding polymers attached to the substrate in a non-covalent manner, said bonding polymers comprising a polysaccharide backbone provided with aromatic groupings and carboxylic acid groupings.

Method for functionalizing surfaces for analyte detection

The invention mainly relates to a method for manufacturing a polypeptide of formula:X&#x2014;X&#x2033;&#x2014;X&#x2003;&#x2003;(III)Xand Xeach representing a peptide fragment, and X&#x2033; representing an amino acid residue comprising a thiol function, said method comprising at least one step of ligation reaction between a polypeptide of formula:X&#x2014;N(CHCHSH)&#x2003;&#x2003;(I)and a polypeptide of formula:H&#x2014;X&#x2033;&#x2014;X.&#x2003;&#x2003;(II) The invention also relates to the polypeptides of formula (I) themselves and the method for obtaining them, as well as resin supports suitable for obtaining them.

Method for native ligation of polypeptides

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La Bassee, France

Julien Dheur