Glycom A/s

Centre National De La Recherche Scientifique

Institut Pasteur

UniversitÉ Paris Descartes

Julien Boutet

Markus Hederos

Lars Kröger

Andreas Schroven

Christoph Röhrig

Piroska Kovács-Pénzes

Ioannis Vrasidas

Gyula Dekany

Christian Risinger

Ágnes Ágoston

István Bajza

Sándor Demkó

Philippe J Sansonetti

Markus Jondelius Hederos

Ferenc Horváth

Károly Ágoston

Ignacio Pérez Figueroa

Gergely Pipa

Laurence Mulard

Armelle Phalipon

Péter Trinka

Farida Nato

Johan Olsson

Istvan Bajza

Catherine Guerreiro

Ignacio Figueroa Pérez

László Kalmár

Gyula Dékany

Elise Champion

Marie Bøjstrup

Krisztián Kovàcs

Ignacio Figueroa-Pérez

Gábor Kádár

Sándor Demkò

Ferenc Horvàth

Ágnes Jànosi

Irme Kovács

Ignacio Figuero-Pérez

Mette Fanefjord

Imre Kovács

Gyula DÉKANY

The present invention relates to compounds derived from sugars which reproduce the epitopes ofserotypes 3a and X and to the use thereof for the preparation of vaccine compositions. More specifically, the subject matter of the present invention relates to novel glycoconjugated compounds comprising oligosaccharides or polysaccharides described hereinafter, to the method for synthesizing these oligosaccharides or polysaccharides and glycoconjugates, to derivatives of these oligosaccharides or polysaccharides, to compositions containing same, and also to the use of the glycoconjugates for vaccination purposes. Finally, the present invention relates to methods for diagnosing ainfection using one or more oligosaccharides or polysaccharides or conjugates thereof.

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The present invention relates to a method for preparation of the trisaccharide 6'-O-sialyllactose (formula (I)) or salts thereof as well as intermediates in the synthesis and for the use of 6&#x2032;-O-sialyllactose salts in pharmaceutical or nutritional compositions. 

Production of 6'-O-sialyllactose and intermediates

The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an &#x3b1;-sialyl moiety and the other is H, Xrepresents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, Ris a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.

Synthesis of sialooligosaccharide derivatives

The present invention relates to an improved synthesis of a trisaccharide of the formula (1), novel intermediates used in the synthesis and the preparation of the intermediates. 

Method for the synthesis of a trisaccharide

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions. 

Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates. 

The present application discloses a method for the crystallization of fucose, characterized in that the crystallization is carried out from a mixture comprising fucose and at least one 6-deoxy sugar selected from 6-deoxy-talose and 6-deoxy-gulose. In one embodiment, the mixture comprises fucose and 6-deoxy-talose.

Method for crystallization of fucose

The present invention relates to novel polymorphs of the trisaccharide 2'-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions. 

Polymorphs of 2'-O-fucosyllactose and producing thereof

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La Plaine sur Mer, France

Julien Boutet